| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics (SAA, IJG, KMH, LL, and KJE); the Section of Endocrinology, Department of Pediatrics (SKG); and the Department of Pathology (GD), Baylor College of Medicine and Texas Children's Hospital, Houston, TX
Background: Short-term studies in adolescents have generally shown an enhancement of calcium absorption by inulin-type fructans (prebiotics). Results have been inconsistent; however, and no studies have been conducted to determine whether this effect persists with long-term use.
Objective: The objective was to assess the effects on calcium absorption and bone mineral accretion after 8 wk and 1 y of supplementation with an inulin-type fructan.
Design: Pubertal adolescents were randomly assigned to receive 8 g/d of a mixed short and long degree of polymerization inulin-type fructan product (fructan group) or maltodextrin placebo (control group). Bone mineral content and bone mineral density were measured before randomization and after 1 y. Calcium absorption was measured with the use of stable isotopes at baseline and 8 wk and 1 y after supplementation. Polymorphisms of the Fok1 vitamin D receptor gene were determined.
Results: Calcium absorption was significantly greater in the fructan group than in the control group at 8 wk (difference: 8.5 ± 1.6%; P < 0.001) and at 1 y (difference: 5.9 ± 2.8%; P = 0.04). An interaction with Fok1 genotype was present such that subjects with an ff genotype had the least initial response to fructan. After 1 y, the fructan group had a greater increment in both whole-body bone mineral content (difference: 35 ± 16 g; P = 0.03) and whole-body bone mineral density (difference: 0.015 ± 0.004 g/cm2; P = 0.01) than did the control group.
Conclusion: Daily consumption of a combination of prebiotic short- and long-chain inulin-type fructans significantly increases calcium absorption and enhances bone mineralization during pubertal growth. Effects of dietary factors on calcium absorption may be modulated by genetic factors, including specific vitamin D receptor gene polymorphisms.
Key Words: Calcium absorption • vitamin D receptor • stable isotopes • inulin • prebiotics • pubertal growth • bioavailability
This article has been cited by other articles:
|
|
 |
|
  J. K. Patterson, X. G. Lei, and D. D. Miller The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption Experimental Biology and Medicine, June 1, 2008; 233(6): 651 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Cashman Diet, Nutrition, and Bone Health J. Nutr., November 1, 2007; 137(11): 2507S - 2512S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Scholz-Ahrens and J. Schrezenmeir Inulin and Oligofructose and Mineral Metabolism: The Evidence from Animal Trials J. Nutr., November 1, 2007; 137(11): 2513S - 2523S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Abrams, I. J. Griffin, and K. M. Hawthorne Young Adolescents Who Respond to an Inulin-Type Fructan Substantially Increase Total Absorbed Calcium and Daily Calcium Accretion to the Skeleton J. Nutr., November 1, 2007; 137(11): 2524S - 2526S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Coxam Current Data with Inulin-Type Fructans and Calcium, Targeting Bone Health in Adults J. Nutr., November 1, 2007; 137(11): 2527S - 2533S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Tuohy Inulin-Type Fructans in Healthy Aging J. Nutr., November 1, 2007; 137(11): 2590S - 2593S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Abrams, K. M. Hawthorne, O. Aliu, P. D. Hicks, Z. Chen, and I. J. Griffin An Inulin-Type Fructan Enhances Calcium Absorption Primarily via an Effect on Colonic Absorption in Humans J. Nutr., October 1, 2007; 137(10): 2208 - 2212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Abrams and G. J. Strewler Adolescence: How Do We Increase Intestinal Calcium Absorption to Allow for Bone Mineral Mass Accumulation? IBMS BoneKEy, May 1, 2007; 4(5): 147 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Scholz-Ahrens, P. Ade, B. Marten, P. Weber, W. Timm, Y. A{varsigma}il, C.-C. Gluer, and J. Schrezenmeir Prebiotics, Probiotics, and Synbiotics Affect Mineral Absorption, Bone Mineral Content, and Bone Structure J. Nutr., March 1, 2007; 137(3): 838S - 846S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Korus, K. Grzelak, K. Achremowicz, and R. Sabat Influence of Prebiotic Additions on the Quality of Gluten-free Bread and on the Content of Inulin and Fructooligosaccharides Food Science and Technology International, December 1, 2006; 12(6): 489 - 495. [Abstract] [PDF]
|
|
|
|
 |
|
 A. G. Ramsay, K. P. Scott, J. C. Martin, M. T. Rincon, and H. J. Flint Cell-associated {alpha}-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology, November 1, 2006; 152(Pt 11): 3281 - 3290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Abrams, I. J. Griffin, K. M. Hawthorne, S. K. Gunn, C. M. Gundberg, and T. O. Carpenter Relationships among Vitamin D Levels, Parathyroid Hormone, and Calcium Absorption in Young Adolescents J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5576 - 5581. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
