| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Departments of Health Sciences and Cell Biology, University of Jyväskylä, Jyväskylä, Finland (SC, AL, MA, QJW, MS, HS, and PHFN); the Department of Biochemistry (CL-A) and the Institute of Biomedicine and Pharmacology (RK), University of Helsinki, Helsinki, Finland; the Departments of Biochemistry and Orthopedic Surgery, Kuopio University Hospital, Kuopio, Finland (AM, SC, and HK); the Central Hospital of Central Finland, Jyväskylä, Finland (AK); the Department of Anatomy, University of Turku, Turku, Finland (KKI and KHV); the Research Center, Valio OY, Finland (RK); the Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden (CO); and the Department of Preventive Medicine, University of Tennessee Health Science Center, Knoxville, TN (FT)
Background: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period.
Objective: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y.
Design: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10–12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography.
Results: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared.
Conclusions: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.
Key Words: Growth • nutrition intervention • pubertal girls • bone property
This article has been cited by other articles:
|
|
 |
|
  K. M Seamans and K. D Cashman Existing and potentially novel functional markers of vitamin D status: a systematic review Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1997S - 2008S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, S. Cheng, M. Alen, E. Seeman, and The Finnish Calex Study Group Bone's Structural Diversity in Adult Females Is Established before Puberty J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1555 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Heaney Dairy and Bone Health J. Am. Coll. Nutr., February 1, 2009; 28(Supplement_1): 82S - 90S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Lamberg-Allardt and H. T Viljakainen 25-Hydroxyvitamin D and functional outcomes in adolescents Am. J. Clinical Nutrition, August 1, 2008; 88(2): 534S - 536S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M Willis, E. M Laing, D. B Hall, D. B Hausman, and R. D Lewis A prospective analysis of plasma 25-hydroxyvitamin D concentrations in white and black prepubertal females in the southeastern United States Am. J. Clinical Nutrition, January 1, 2007; 85(1): 124 - 130. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
