HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakamura, K. Articles by Yamamoto, M. Search for Related Content PubMed PubMed Citation Articles by Nakamura, K. Articles by Yamamoto, M. Agricola Articles by Nakamura, K. Articles by Yamamoto, M.

Nutrition, mild hyperparathyroidism, and bone mineral density in young Japanese women^1,2,3

¹ From the Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan (KN, YO, YT, and MY); the Department of Nursing, School of Health Sciences, Niigata University, Niigata City, Japan (KU and TN); and the Department of Health and Nutrition, Niigata University of Health and Welfare, Niigata City, Japan (TS)

Background: The adverse effects of poor nutrition on the bones of young Asian women have not been fully elucidated.

Objective: The purpose of this study was to investigate possible associations of vitamin D nutrition, calcium intake, and other nutrients with bone metabolism and bone mass in young Japanese women.

Design: The subjects were 108 female college students aged 19-25 y. Dietary nutrients were measured by using the duplicate sampling method on 3 weekdays. Serum 25-hydroxyvitamin D [25(OH)D], intact parathyroid hormone, and bone turnover markers were also measured. Bone mineral density (BMD) of the spine and femur was measured by dual-energy X-ray absorptiometry.

Results: The proportions of the subjects with low 25(OH)D (<30 nmol/L) and high intact parathyroid hormone (6.9 pmol/L) concentrations were 32.4% and 15.7%, respectively. Serum 25(OH)D concentrations (P = 0.0265) and calcium intake (P = 0.0103) were inversely associated with serum intact parathyroid hormone. In addition to weight and physical activity, the presence of mild hyperparathyroidism was associated with a low BMD of the lumbar spine (P = 0.0062) and the femoral neck (P = 0.0250), and a low calcium intake was associated with a low BMD of the femoral neck (P = 0.0044).

Conclusions: Low calcium intake (based on low BMD of the femoral neck only) and mild hyperparathyroidism (based on low BMD of both the femoral neck and lumbar spine), partly explained by low vitamin D nutrition and a low calcium intake, are important predictors of low BMD in young Japanese women. Effects of poor nutrition and mild hyperparathyroidism on bone peak bone mass in young women should be further investigated in longitudinal studies.

Key Words: Bone density • calcium-to-phosphorus ratio • dietary calcium • 25-hydroxyvitamin D • hyperparathyroidism • Japanese • vitamin D • vitamin K • young women

This article has been cited by other articles:

				R. Vieth, H. Bischoff-Ferrari, B. J Boucher, B. Dawson-Hughes, C. F Garland, R. P Heaney, M. F Holick, B. W Hollis, C. Lamberg-Allardt, J. J McGrath, et al. The urgent need to recommend an intake of vitamin D that is effective Am. J. Clinical Nutrition, March 1, 2007; 85(3): 649 - 650. [Full Text] [PDF]