| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Human Biology, Maastricht University, Maastricht, Netherlands
Background: The mechanism of protein-induced satiety remains unclear.
Objective: The objective was to investigate 24-h satiety and related hormones and energy and substrate metabolism during a high-protein (HP) diet in a respiration chamber.
Design: Twelve healthy women aged 18–40 y were fed in energy balance an adequate-protein (AP: 10%, 60%, and 30% of energy from protein, carbohydrate, and fat, respectively) or an HP (30%, 40%, and 30% of energy from protein, carbohydrate, and fat, respectively) diet in a randomized crossover design. Substrate oxidation, 24-h energy expenditure (EE), appetite profile, and ghrelin and glucagon-like peptide 1 (GLP-1) concentrations were measured.
Results: Sleeping metabolic rate (6.40 ± 0.47 compared with 6.12 ± 0.40 MJ/d; P < 0.05), diet-induced thermogenesis (0.91 ± 0.25 compared with 0.69 ± 0.24 MJ/d; P < 0.05), and satiety were significantly higher, and activity-induced EE (1.68 ± 0.32 compared with 1.86 ± 0.41; P < 0.05), respiratory quotient (0.84 ± 0.02 compared with 0.88 ± 0.03; P < 0.0005), and hunger were significantly lower during the HP diet. There was a tendency for a greater 24-h EE during the HP diet (P = 0.05). Although energy intake was not significantly different between the diet groups, the subjects were in energy balance during the HP diet and in positive energy balance during the AP diet. Satiety was related to 24-h protein intake (r2 = 0.49, P < 0.05) only during the HP diet. Ghrelin concentrations were not significantly different between diets. GLP-1 concentrations after dinner were higher during the HP than during the AP diet (P < 0.05).
Conclusion: An HP diet, compared with an AP diet, fed at energy balance for 4 d increased 24-h satiety, thermogenesis, sleeping metabolic rate, protein balance, and fat oxidation. Satiety was related to protein intake, and incidentally to ghrelin and GLP-1 concentrations, only during the HP diet.
Key Words: Satiety • high-protein diet • ghrelin • glucagon-like peptide 1 • GLP-1 • energy balance
This article has been cited by other articles:
|
|
 |
|
  R. Faipoux, D. Tome, S. Gougis, N. Darcel, and G. Fromentin Proteins Activate Satiety-Related Neuronal Pathways in the Brainstem and Hypothalamus of Rats J. Nutr., June 1, 2008; 138(6): 1172 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Paddon-Jones, E. Westman, R. D Mattes, R. R Wolfe, A. Astrup, and M. Westerterp-Plantenga Protein, weight management, and satiety Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1558S - 1561S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Smeets, S. Soenen, N. D. Luscombe-Marsh, O. Ueland, and M. S. Westerterp-Plantenga Energy Expenditure, Satiety, and Plasma Ghrelin, Glucagon-Like Peptide 1, and Peptide Tyrosine-Tyrosine Concentrations following a Single High-Protein Lunch J. Nutr., April 1, 2008; 138(4): 698 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J Moran, M. Noakes, P. M Clifton, G. A Wittert, C. W Le Roux, M. A Ghatei, S. R Bloom, and R. J Norman Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1603 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. P Lee, T. A Mori, S. Sipsas, A. Barden, I. B Puddey, V. Burke, R. S Hall, and J. M Hodgson Lupin-enriched bread increases satiety and reduces energy intake acutely. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 975 - 980. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
