HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McVeigh, B. L Articles by Duncan, A. M Search for Related Content PubMed PubMed Citation Articles by McVeigh, B. L Articles by Duncan, A. M Agricola Articles by McVeigh, B. L Articles by Duncan, A. M

Effect of soy protein varying in isoflavone content on serum lipids in healthy young men^1,2,3

¹ From the Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada (BLM, BLD, and AMD), and the Fred Hutchinson Cancer Research Center, Seattle, WA (JWL)

Background: Previous research supports a role for soy protein in reducing serum lipids; however, few studies involved healthy male subjects or focused on soy isoflavones (or did both).

Objective: The objective was to ascertain the effects of soy protein varying in isoflavone content on serum lipids in healthy young men.

Design: Thirty-five males ( ± SD age: 27.9 ± 5.7 y) consumed milk protein isolate (MPI), low-isoflavone soy protein isolate (low-iso SPI; 1.64 ± 0.19 mg aglycone isoflavones/d), and high-isoflavone SPI (high-iso SPI; 61.7 ± 7.4 mg aglycone isoflavones/d) for 57 d each, separated by 4-wk washout periods, in a randomized crossover design. Blood samples were collected at the beginning and end of each treatment period, and total, LDL, and HDL cholesterol; triacylglycerols; apolipoprotein (apo) B; apo A-I; and C-reactive protein (CRP) were measured in serum. Twenty-four-hour urine samples were collected for 3 consecutive days at the end of each treatment period and analyzed for isoflavones.

Results: Urinary isoflavones were significantly greater with consumption of the high-iso SPI than with that of the low-iso SPI or MPI. The differences between the 3 treatments with respect to individual serum lipids were not significant, but the ratios of total to HDL cholesterol, LDL to HDL cholesterol, and apo B to apo A-I were significantly lower with both SPI treatments than with MPI treatment.

Conclusion: Soy protein, regardless of isoflavone content, modulates serum lipid ratios in a direction beneficial for cardiovascular disease risk in healthy young men.

Key Words: Soy protein • isoflavones • healthy men • serum lipids • lipid ratios • C-reactive protein

This article has been cited by other articles:

				O. K. Chun, S.-J. Chung, K. J. Claycombe, and W. O. Song Serum C-Reactive Protein Concentrations Are Inversely Associated with Dietary Flavonoid Intake in U.S. Adults J. Nutr., April 1, 2008; 138(4): 753 - 760. [Abstract] [Full Text] [PDF]

				K. Taku, K. Umegaki, Y. Sato, Y. Taki, K. Endoh, and S. Watanabe Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1148 - 1156. [Abstract] [Full Text] [PDF]

				L. Azadbakht, M. Kimiagar, Y. Mehrabi, A. Esmaillzadeh, M. Padyab, F. B Hu, and W. C Willett Soy inclusion in the diet improves features of the metabolic syndrome: a randomized crossover study in postmenopausal women Am. J. Clinical Nutrition, March 1, 2007; 85(3): 735 - 741. [Abstract] [Full Text] [PDF]