| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Medical Research Council Epidemiology Unit, Cambridge, United Kingdom (UE, SB, and NJW); the Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (KO and DBD); and the Obesity Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (YL, MN, and SR)
Background: Rapid early postnatal weight gain predicts increased subsequent obesity and related disease risks. However, the exact timing of adverse rapid postnatal weight gain is unclear.
Objective: The objective was to examine the associations between rapid weight gain in infancy and in early childhood in relation to body composition at age 17 y.
Design: This prospective cohort study was conducted in 248 (103 males) singletons and their mothers. Height and weight were measured at birth, 6 mo, and 3 and 6 y. The rates of weight gain during infancy (0–6 mo) and early childhood (3–6 y) were calculated as changes in sex- and age-adjusted weight SD scores during these time periods. At 17 y, body composition was measured by air-displacement plethysmography.
Results: Increasing weight gain during infancy and early childhood were both independently associated with larger body mass index, fat mass, relative fat mass, fat-free mass, and waist circumference at 17 y (P < 0.005 for all; adjusted for sex, birth weight, gestational age, current height, maternal socioeconomic status, and maternal fat mass). Rapid weight gain in infancy, but not in early childhood, also predicted taller height at 17 y (P < 0.001).
Conclusions: Rapid weight gain in both infancy and early childhood is a risk factor for adult adiposity and obesity. Rapid weight gain in infancy also predicted taller adult height. We hypothesize that rapid weight gains in infancy and early childhood are different processes and may allow separate opportunities for early intervention against obesity risk later in life.
Key Words: Air-displacement plethysmography • catch-up growth • weight gain • obesity • Stockholm Weight Development Study
This article has been cited by other articles:
|
|
 |
|
  M. Ceelen, M. M. van Weissenbruch, J. Prein, J. J. Smit, J. P.W. Vermeiden, M. Spreeuwenberg, F. E. van Leeuwen, and H. A. Delemarre-van de Waal Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8-18 years of IVF children and spontaneously conceived controls born to subfertile parents Hum. Reprod., November 1, 2009; 24(11): 2788 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Beardsall, K. K. Ong, N. Murphy, M. L. Ahmed, J. H. Zhao, M. W. Peeters, and D. B. Dunger Heritability of Childhood Weight Gain from Birth and Risk Markers for Adult Metabolic Disease in Prepubertal Twins J. Clin. Endocrinol. Metab., October 1, 2009; 94(10): 3708 - 3713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. J. Leunissen, G. F. Kerkhof, T. Stijnen, and A. Hokken-Koelega Timing and Tempo of First-Year Rapid Growth in Relation to Cardiovascular and Metabolic Risk Profile in Early Adulthood JAMA, June 3, 2009; 301(21): 2234 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Ong, P. Emmett, K. Northstone, J. Golding, I. Rogers, A. R. Ness, J. C. Wells, and D. B. Dunger Infancy Weight Gain Predicts Childhood Body Fat and Age at Menarche in Girls J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1527 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. L. Gardner, J. Hosking, B. S. Metcalf, A. N. Jeffery, L. D. Voss, and T. J. Wilkin Contribution of Early Weight Gain to Childhood Overweight and Metabolic Health: A Longitudinal Study (EarlyBird 36) Pediatrics, January 1, 2009; 123(1): e67 - e73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lagstrom, M. Hakanen, H. Niinikoski, J. Viikari, T. Ronnemaa, M. Saarinen, K. Pahkala, and O. Simell Growth Patterns and Obesity Development in Overweight or Normal-Weight 13-Year-Old Adolescents: The STRIP Study Pediatrics, October 1, 2008; 122(4): e876 - e883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Krebs, J. H. Himes, D. Jacobson, T. A. Nicklas, P. Guilday, and D. Styne Assessment of Child and Adolescent Overweight and Obesity Pediatrics, December 1, 2007; 120(Supplement_4): S193 - S228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Gale, M. K. Javaid, S. M. Robinson, C. M. Law, K. M. Godfrey, and C. Cooper Maternal Size in Pregnancy and Body Composition in Children J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3904 - 3911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Cohen Current Issues in Human Milk Banking NeoReviews, July 1, 2007; 8(7): e289 - e295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Ekelund, K. K. Ong, Y. Linne, M. Neovius, S. Brage, D. B. Dunger, N. J. Wareham, and S. Rossner Association of Weight Gain in Infancy and Early Childhood with Metabolic Risk in Young Adults J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 98 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Robbins, K. S. Khan, L. M. Lisi, S. W. Robbins, S. H. Michel, and B. R. Torcato Overweight Among Young Children in the Philadelphia Health Care Centers: Incidence and Prevalence Arch Pediatr Adolesc Med, January 1, 2007; 161(1): 17 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Karaolis-Danckert, A. E Buyken, K. Bolzenius, C. Perim de Faria, M. J Lentze, and A. Kroke Rapid growth among term children whose birth weight was appropriate for gestational age has a longer lasting effect on body fat percentage than on body mass index Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1449 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Heude, C. J. Petry, the Avon Longitudinal Study of Parents Children (A, M. Pembrey, D. B. Dunger, and K. K. Ong The Insulin Gene Variable Number of Tandem Repeat: Associations and Interactions with Childhood Body Fat Mass and Insulin Secretion in Normal Children J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2770 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ibanez, K. Ong, D. B. Dunger, and F. de Zegher Early Development of Adiposity and Insulin Resistance after Catch-Up Weight Gain in Small-for-Gestational-Age Children J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2153 - 2158. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
