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ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Epidemiology, Departments of Public Health and Forensic Medicine (SK, AH, KO, TS, and IT), Geriatric and Respiratory Medicine (TM and SE), and Psychiatry (SA), the Division of Medicine and Science in Sports and Exercise, Departments of Functional Medical Science (RN) and Geriatric and Complementary Medicine (HA), Tohoku University Graduate School of Medicine, Sendai, Japan
Background: Although considerable experimental and animal evidence shows that green tea may possess potent activities of neuroprotection, neurorescue, and amyloid precursor protein processing that may lead to cognitive enhancement, no human data are available.
Objective: The objective was to examine the association between green tea consumption and cognitive function in humans.
Design: We analyzed cross-sectional data from a community-based Comprehensive Geriatric Assessment (CGA) conducted in 2002. The subjects were 1003 Japanese subjects aged 
70 y. They completed a self-administered questionnaire that included questions about the frequency of green tea consumption. We evaluated cognitive function by using the Mini-Mental State Examination with cutoffs of <28, <26, and <24 and calculated multivariate-adjusted odds ratios (ORs) of cognitive impairment.
Results: Higher consumption of green tea was associated with a lower prevalence of cognitive impairment. At the <26 cutoff, after adjustment for potential confounders, the ORs for the cognitive impairment associated with different frequencies of green tea consumption were 1.00 (reference) for 
3 cups/wk, 0.62 (95% CI: 0.33, 1.19) for 4–6 cups/wk or 1 cup/d, and 0.46 (95% CI: 0.30, 0.72) for 2 cups/d (P for trend = 0.0006). Corresponding ORs were 1.00 (reference), 0.60 (95% CI: 0.35, 1.02), and 0.87 (95% CI: 0.55, 1.38) (P for trend = 0.33) for black or oolong tea and 1.00 (reference), 1.16 (95% CI: 0.78, 1.73), and 1.03 (95% CI: 0.59, 1.80) (P for trend = 0.70) for coffee. The results were essentially the same at cutoffs of <28 and <24.
Conclusion: A higher consumption of green tea is associated with a lower prevalence of cognitive impairment in humans.
Key Words: Cognitive function • elderly • green tea • Japanese • Mini-Mental State Examination
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