HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mundy, G. R Search for Related Content PubMed PubMed Citation Articles by Mundy, G. R Agricola Articles by Mundy, G. R

Nutritional modulators of bone remodeling during aging^1,2,3

¹ From the University of Texas Health Science Center at San Antonio, Texas

ABSTRACT

Bone mass declines progressively with age in both men and women from the age of 30 y. Increased longevity will inevitability be associated with an increase in the incidence of osteoporosis, its associated complications, and incurred health care costs. Current pharmacologic approaches focus on inhibiting bone resorption in those with osteoporosis but do little to improve bone mass. Increased understanding of the cellular events responsible for normal bone formation has led to multiple pathways that can be targeted to positively influence bone mass. Bone morphogenetic proteins (BMPs) have been shown to stimulate bone formation, and the BMP2 gene was recently linked to osteoporosis. BMP-2 therefore represents one potential molecular target to identify new agents to simulate bone formation. Research is accumulating on the positive effects of dietary sources that stimulate the BMP2 promoter and their effects on bone formation. Flavonoids and statins occur naturally in food products and have been shown to promote bone formation. It may be possible to influence peak bone mass by dietary means and to decrease the risk of osteoporosis in later life. To ease the future burden of osteoporosis, focusing on prevention will be key, and this could include dietary interventions to stimulate bone formation.

Key Words: Osteoporosis • flavonoid • statin • lovastatin • bone mass • osteoclast • osteoblast • osteoblast proliferation • osteoblast differentiation • resorption inhibitor • red yeast rice • bone morphogenetic protein • BMP • bone remodeling • myeloma • nutritional supplements • dietary supplements

This article has been cited by other articles:

				J. M Hodgson, A. Devine, V. Burke, I. M Dick, and R. L Prince Chocolate consumption and bone density in older women Am. J. Clinical Nutrition, January 1, 2008; 87(1): 175 - 180. [Abstract] [Full Text] [PDF]

				L. S. H. Nissen-Meyer, R. Jemtland, V. T. Gautvik, M. E. Pedersen, R. Paro, D. Fortunati, D. D. Pierroz, V. A. Stadelmann, S. Reppe, F. P. Reinholt, et al. Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice J. Cell Sci., August 15, 2007; 120(16): 2785 - 2795. [Abstract] [Full Text] [PDF]

				J.-L. Su, C.-Y. Yang, M. Zhao, M.-L. Kuo, and M.-L. Yen Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol J. Biol. Chem., July 6, 2007; 282(27): 19385 - 19398. [Abstract] [Full Text] [PDF]