HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ordovas, J. M Search for Related Content PubMed PubMed Citation Articles by Ordovas, J. M Agricola Articles by Ordovas, J. M

Genetic interactions with diet influence the risk of cardiovascular disease^1,2,3

¹ From the Tufts University Sackler School of Graduate Biomedical Sciences, the Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, and the Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA

ABSTRACT

Single-nucleotide polymorphisms are an integral component of the evolutionary process that over millennia have resulted from the interaction between the environment and the human genome. Relatively recent changes in diet have upset this interaction with respect to the nutritional environment, but nutritional science is beginning to better understand the interaction between genes and diet, with the resulting potential to influence cardiovascular disease risk by dietary modification. Single-nucleotide polymorphisms in several genes have been linked to differential effects in terms of lipid metabolism; however, even a simple model of benefit and risk is difficult to interpret in terms of dietary advice to carriers of the various alleles because of conflicting interactions between different genes. The n–3 family of polyunsaturated fatty acids is underrepresented in our modern diet; much of the benefit of polyunsaturated fatty acids found in studies of various polymorphisms seems to be linked to increased n–3 polyunsaturated fatty acid intake. The nascent science of nutrigenomics faces many challenges; more and better research is needed to clarify the picture, rebut scepticism, and re-invigorate the discussion concerning genetic polymorphism and its interaction with diet.

Key Words: Cardiovascular disease • cardiovascular risk • polymorphism • apolipoprotein • apolipoprotein A-I • APOA1 • apolipoprotein A-V • APOA5 • HDL cholesterol • triacylglycerol • polyunsaturated fatty acids

This article has been cited by other articles:

				C. E. O'Neil and T. A. Nicklas State of the Art Reviews: Relationship Between Diet/ Physical Activity and Health American Journal of Lifestyle Medicine, December 1, 2007; 1(6): 457 - 481. [Abstract] [PDF]

				S. H Zeisel Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline Am. J. Clinical Nutrition, September 1, 2007; 86(3): 542 - 548. [Abstract] [Full Text] [PDF]

				A. M Zivkovic and J B. German Individual variation in the metabolic syndrome: a new perspective on the debate Am. J. Clinical Nutrition, January 1, 2007; 85(1): 240 - 241. [Full Text] [PDF]