| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Supplement: Living Well to 100: Nutrition, Genetics, Inflammation |
1 From the Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO
ABSTRACT
In this review, 2 cytokines are discussed with respect to the inflammatory processes that are fundamental to aging and mortality. Both interleukin (IL)-1 and IL-18 are members of the same structural family (IL-1 family, or IL-F); there are presently 9 members of this family, but with the exception of IL-1
, IL-1ß, and IL-18, the others are antagonists or remain without known function. IL-1 is an intracellular cytokine with properties of both a cytokine and a transcription factor. IL-1ß and IL-18 are closely related; both possess a similar three-dimensional structure, and their respective precursor forms are inactive until cleaved by the intracellular cysteine protease caspase-1. Patients with mutations in the NALP3 gene, which controls the activity of caspase-1, readily secrete more IL-1ß and IL-18 and suffer from systemic inflammatory diseases. Patients with defects in this gene have high circulating concentrations of IL-6, serum amyloid A, and C-reactive protein, each of which decrease rapidly upon blockade of the IL-1 receptor, which suggests that IL-1ß contributes to the elevation of these markers of the inflammatory mechanisms of aging. Animal studies support the concept that IL-1ß and IL-18 participate in the pathogenesis of atherosclerosis. For example, overexpression of the IL-18 binding protein, a naturally occurring, specific inhibitor of IL-18, prevents the spontaneous development of atherosclerosis in apolipoprotein E–deficient mice. From human and animal studies, one may conclude that IL-1ß and IL-18 participate in fundamental inflammatory processes that increase during the aging process.
Key Words: Cytokines • inflammation • atherosclerosis • aging
This article has been cited by other articles:
|
|
 |
|
  K. Thomas, S. Rafiq, T. M. Frayling, S. Ebrahim, M. Kumari, J. Gallacher, L. Ferrucci, S. Bandinelli, R. B. Wallace, D. Melzer, et al. Interleukin-18 Polymorphism and Physical Functioning in Older People: A Replication Study and Meta-Analysis J Gerontol A Biol Sci Med Sci, November 1, 2009; 64A(11): 1177 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Abdul-Sater, E. Koo, G. Hacker, and D. M. Ojcius Inflammasome-dependent Caspase-1 Activation in Cervical Epithelial Cells Stimulates Growth of the Intracellular Pathogen Chlamydia trachomatis J. Biol. Chem., September 25, 2009; 284(39): 26789 - 26796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Haddad, L. K. Senger, and F. Takei An Accessory Role for B Cells in the IL-12-Induced Activation of Resting Mouse NK Cells J. Immunol., September 15, 2009; 183(6): 3608 - 3615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. COLBERT, A. A. DEODHAR, D. FOX, E. M. GRAVALLESE, M. A. KHAN, D. McGONAGLE, J. D. REVEILLE, G. SCHETT, M. WEISMAN, D. O. CLEGG, et al. Entheses and Bones in Spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN) J Rheumatol, July 1, 2009; 36(7): 1527 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Murdolo, C. Herder, Z. Wang, B. Rose, M. Schmelz, and P.-A. Jansson In situ profiling of adipokines in subcutaneous microdialysates from lean and obese individuals Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1095 - E1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lilo, Y. Zheng, and J. B. Bliska Caspase-1 Activation in Macrophages Infected with Yersinia pestis KIM Requires the Type III Secretion System Effector YopJ Infect. Immun., September 1, 2008; 76(9): 3911 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Mares, S. S. Ojeda, E. G. Morris, Q. Li, and J. M. Teale Initial Delay in the Immune Response to Francisella tularensis Is Followed by Hypercytokinemia Characteristic of Severe Sepsis and Correlating with Upregulation and Release of Damage-Associated Molecular Patterns Infect. Immun., July 1, 2008; 76(7): 3001 - 3010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, S. B. Willingham, J. P.-Y. Ting, and F. Re Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3 J. Immunol., July 1, 2008; 181(1): 17 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Huang, J.-J. Liao, S. Bonasera, D. L. Longo, and E. J. Goetzl Nuclear factor-{kappa}B-dependent reversal of aging-induced alterations in T cell cytokines FASEB J, July 1, 2008; 22(7): 2142 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yajima, M. Takahashi, H. Morimoto, Y. Shiba, Y. Takahashi, J. Masumoto, H. Ise, J. Sagara, J. Nakayama, S. Taniguchi, et al. Critical Role of Bone Marrow Apoptosis-Associated Speck-Like Protein, an Inflammasome Adaptor Molecule, in Neointimal Formation After Vascular Injury in Mice Circulation, June 17, 2008; 117(24): 3079 - 3087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. de Rivero Vaccari, G. Lotocki, A. E. Marcillo, W. D. Dietrich, and R. W. Keane A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury J. Neurosci., March 26, 2008; 28(13): 3404 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Marina-Garcia, L. Franchi, Y.-G. Kim, D. Miller, C. McDonald, G.-J. Boons, and G. Nunez Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2 J. Immunol., March 15, 2008; 180(6): 4050 - 4057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Skrovanek, M. C. Valenzano, and J. M. Mullin Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1046 - R1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bossu, A. Ciaramella, M. L. Moro, L. Bellincampi, S. Bernardini, G. Federici, A. Trequattrini, F. Macciardi, I. Spoletini, F. Di Iulio, et al. Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 807 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Frasca, A. M. Landin, J. P. Alvarez, P. J. Blackshear, R. L. Riley, and B. B. Blomberg Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA J. Immunol., July 15, 2007; 179(2): 918 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Zorrilla, M. Sanchez-Alavez, S. Sugama, M. Brennan, R. Fernandez, T. Bartfai, and B. Conti Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency PNAS, June 26, 2007; 104(26): 11097 - 11102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Li, Z. Huang, R. Kingsley, X. Zhou, F. Li, D. W. Parke II, and W. Cao Biochemical Alterations in the Retinas of Very Low-Density Lipoprotein Receptor Knockout Mice: An Animal Model of Retinal Angiomatous Proliferation Arch Ophthalmol, June 1, 2007; 125(6): 795 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Cruz, A. Rinna, H. J. Forman, A. L. M. Ventura, P. M. Persechini, and D. M. Ojcius ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages J. Biol. Chem., February 2, 2007; 282(5): 2871 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. O. Enwonwu and C. S. Ritchie Nutrition and inflammatory markers J Am Dent Assoc, January 1, 2007; 138(1): 70 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Frayling, S. Rafiq, A. Murray, A. J. Hurst, M. N. Weedon, W. Henley, S. Bandinelli, A.-M. Corsi, L. Ferrucci, J. M. Guralnik, et al. An Interleukin-18 Polymorphism Is Associated With Reduced Serum Concentrations and Better Physical Functioning in Older People J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 73 - 78. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
