| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences (ST, ELJ, EM, WLH, CMW, and PY) and the School of Animal and Microbial Sciences (ABG and DSL), The University of Reading, Reading, United Kingdom, and the Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom (GCB, JJR, SE-K, RFG, and PCC)
Background: Interest in the development of dairy products naturally enriched in conjugated linoleic acid (CLA) exists. However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known.
Objective: This study investigated the effects of consuming dairy products naturally enriched in cis-9,trans-11 CLA (and trans-11 18:1) on the blood lipid profile, the atherogenicity of LDL, and markers of inflammation and insulin resistance in healthy middle-aged men.
Design: Healthy middle-aged men (n = 32) consumed ultra-heat-treated milk, butter, and cheese that provided 0.151 g/d (control) or 1.421 g/d (modified) cis-9,trans-11 CLA for 6 wk. This was followed by a 7-wk washout and a crossover to the other treatment.
Results: Consumption of dairy products enriched with cis-9,trans-11 CLA and trans-11 18:1 did not significantly affect body weight, inflammatory markers, insulin, glucose, triacylglycerols, or total, LDL, and HDL cholesterol but resulted in a small increase in the ratio of LDL to HDL cholesterol. The modified dairy products changed LDL fatty acid composition but had no significant effect on LDL particle size or the susceptibility of LDL to oxidation. Overall, increased consumption of full-fat dairy products and naturally derived trans fatty acids did not cause significant changes in cardiovascular disease risk variables, as may be expected on the basis of current health recommendations.
Conclusion: Dairy products naturally enriched with cis-9,trans-11 CLA and trans-11 18:1 do not appear to have a significant effect on the blood lipid profile.
Key Words: Cholesterol • conjugated linoleic acid • high-density lipoprotein • low-density lipoprotein • triacylglycerol
This article has been cited by other articles:
|
|
 |
|
  M. Manco, G. Bottazzo, R. DeVito, M. Marcellini, G. Mingrone, and V. Nobili Nonalcoholic Fatty Liver Disease in Children J. Am. Coll. Nutr., December 1, 2008; 27(6): 667 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Willett and D. Mozaffarian Ruminant or industrial sources of trans fatty acids: public health issue or food label skirmish? Am. J. Clinical Nutrition, March 1, 2008; 87(3): 515 - 516. [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Chardigny, F. Destaillats, C. Malpuech-Brugere, J. Moulin, D. E Bauman, A. L Lock, D. M Barbano, R. P Mensink, J.-B. Bezelgues, P. Chaumont, et al. Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study Am. J. Clinical Nutrition, March 1, 2008; 87(3): 558 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Raff, T. Tholstrup, S. Basu, P. Nonboe, M. T. Sorensen, and E. M. Straarup A Diet Rich in Conjugated Linoleic Acid and Butter Increases Lipid Peroxidation but Does Not Affect Atherosclerotic, Inflammatory, or Diabetic Risk Markers in Healthy Young Men J. Nutr., March 1, 2008; 138(3): 509 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mozaffarian Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern? Int. J. Epidemiol., February 1, 2008; 37(1): 182 - 184. [Full Text] [PDF]
|
|
|
|
|
|
A. M Zivkovic, J B. German, and A. J Sanyal Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease Am. J. Clinical Nutrition, August 1, 2007; 86(2): 285 - 300. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
