| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Preventive and Behavioral Medicine (YM, JAG, BCO, WL, SLP, and ARH) and the Division of Cardiovascular Medicine (EJ and ISO), University of Massachusetts Medical School, Worcester, MA; and the Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA (LC-T and EJS)
Background:High sensitivity C-reactive protein (CRP) is a marker of acute inflammation recently recognized as an independent predictor of future cardiovascular disease and diabetes. The identification of modifiable factors, such as diet, that influence serum CRP concentrations may provide the means for reducing the risk of these diseases. Data on longitudinal associations between dietary fiber intake and CRP are currently lacking.
Objective:The purpose of this study was to examine longitudinal associations between dietary fiber intake and CRP.
Design:Data collection took place at baseline and quarterly (every 13 wk) thereafter for a total of 5 visits, each including measurements of body composition, CRP, diet, and physical activity. Relations between serum CRP and dietary fiber were assessed by using linear mixed models and logistic regression, adjusted for covariates.
Results:A total of 524 subjects had multiple measurements of CRP and dietary factors. The average total dietary fiber intake was 16.11 g/d. Average serum CRP was 1.78 mg/L. We observed an inverse association between intake of total dietary fiber (separately for soluble and insoluble fiber) and CRP concentrations in both cross-sectional and longitudinal analyses. The likelihood of elevated CRP concentrations was 63% lower (OR: 0.37; 95% CI: 0.16, 0.87) in participants in the highest quartile of total fiber intake than in participants in the lowest quartile.
Conclusions:Our results suggest that dietary fiber is protective against high CRP, which supports current recommendations for a diet high in fiber.
Key Words: Dietary fiber • C-reactive protein • epidemiology • cardiovascular disease • nutrition
This article has been cited by other articles:
|
|
 |
|
  T. E. Weber, C. J. Ziemer, and B. J. Kerr Effects of adding fibrous feedstuffs to the diet of young pigs on growth performance, intestinal cytokines, and circulating acute-phase proteins J Anim Sci, April 1, 2008; 86(4): 871 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. King, A. G. Mainous III, B. M. Egan, R. F. Woolson, and M. E. Geesey Effect of Psyllium Fiber Supplementation on C-Reactive Protein: The Trial to Reduce Inflammatory Markers (TRIM) Ann. Fam. Med, March 1, 2008; 6(2): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Weickert and A. F. H. Pfeiffer Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes J. Nutr., March 1, 2008; 138(3): 439 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kan, J. Stevens, G. Heiss, K. M. Rose, and S. J. London Dietary Fiber, Lung Function, and Chronic Obstructive Pulmonary Disease in the Atherosclerosis Risk in Communities Study Am. J. Epidemiol., March 1, 2008; 167(5): 570 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. O'Keefe, N. M. Gheewala, and J. O. O'Keefe Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health J. Am. Coll. Cardiol., January 22, 2008; 51(3): 249 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kan, J. Stevens, G. Heiss, R. Klein, K. M Rose, and S. J London Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1626 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L Pierce, M. A Austin, P. K Crane, B. M Retzlaff, B. Fish, C. M Hutter, D. L Leonetti, and W. Y Fujimoto Measuring dietary acculturation in Japanese Americans with the use of confirmatory factor analysis of food-frequency data Am. J. Clinical Nutrition, August 1, 2007; 86(2): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Esmaillzadeh, M. Kimiagar, Y. Mehrabi, L. Azadbakht, F. B. Hu, and W. C. Willett Dietary Patterns and Markers of Systemic Inflammation among Iranian Women J. Nutr., April 1, 2007; 137(4): 992 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Baschetti, Y. Ma, B. C. Olendzki, A. R. Hafner, D. E. Chiriboga, W. Li, J. R. Hebert, Y. Li, K. Leung, and I. S. Ockene Carbohydrate intake, serum lipids, and evolution. J. Am. Coll. Nutr., October 1, 2006; 25(5): 437 - 438. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
