HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stephensen, C. B Articles by Wilson, C. M Search for Related Content PubMed PubMed Citation Articles by Stephensen, C. B Articles by Wilson, C. M Agricola Articles by Stephensen, C. B Articles by Wilson, C. M

Vitamin D status in adolescents and young adults with HIV infection^1,2,3

¹ From the US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center at the University of California, Davis, CA (CBS); the Department of Nutrition, University of California, Davis, CA (CBS); the Department of Food Science and Human Nutrition, Iowa State University, Ames, IA (GSM and LAK); the Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children's Hospital of Pennsylvania, Philadelphia, PA (SDD); the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA (SDD); the Saban Research Institute at the Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA (GMA); and the Department of Pediatrics and Medicine, University of Alabama at Birmingham, Birmingham, AL (CMW)

Background: Vitamin D status affects immune function and thus may affect the progress of HIV infection.

Objectives: Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched control subjects and to determine whether HIV infection was associated with vitamin D insufficiency.

Design: Plasma 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D intake were measured in a cross-sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort.

Results: The subjects were aged 14–23 y; 74% were female, and 72% were black. Mean (±SE) vitamin D intake from food was 30% greater (P = 0.023) in HIV-positive subjects (295 ± 18 IU/d; n = 237) than in HIV-negative subjects (227 ± 26 IU/d; n = 121). The prevalence of vitamin D supplement use was 29% (104 of 358 subjects) and did not differ significantly by HIV status (P = 0.87). Mean plasma 25(OH)D did not differ significantly (P = 0.62) between the HIV-positive (20.3 ± 1.1 nmol/L; n = 238) and HIV-negative (19.3 ± 1.7 nmol/L; n = 121) subjects, nor was HIV status a significant predictor of plasma 25(OH)D when multiple regression analysis was used to adjust for other variables. The prevalence of vitamin D insufficiency [plasma 25(OH)D 37.5 nmol/L] in the subjects was 87% (312 of 359 subjects).

Conclusions: HIV infection did not influence vitamin D status. The prevalence of vitamin D insufficiency in both HIV-positive and HIV-negative REACH subjects was high, perhaps because these disadvantaged, largely urban youth have limited sun exposure.

Key Words: Vitamin D • HIV infection • dietary intake • adolescents • race

This article has been cited by other articles:

				S. M. Arpadi, D. McMahon, E. J. Abrams, M. Bamji, M. Purswani, E. S. Engelson, M. Horlick, and E. Shane Effect of Bimonthly Supplementation With Oral Cholecalciferol on Serum 25-Hydroxyvitamin D Concentrations in HIV-Infected Children and Adolescents Pediatrics, January 1, 2009; 123(1): e121 - e126. [Abstract] [Full Text] [PDF]