HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nettleton, J. A Articles by Jacobs, D. R Search for Related Content PubMed PubMed Citation Articles by Nettleton, J. A Articles by Jacobs, D. R, Jr Agricola Articles by Nettleton, J. A Articles by Jacobs, D. R

Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA) ^1,2,3

¹ From the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (JAN, LMS, and DRJ); the Department of Nutrition, University of Oslo, Oslo, Norway (DRJ); the Center for Research in Nutrition and Health Disparities and the Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC (EJM-D); the Department of Pathology, University of Vermont, Burlington, VT (NSJ); the Columbia University, New York, NY (RJ); and the Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (DMH)

Background: Dietary patterns may influence cardiovascular disease risk through effects on inflammation and endothelial activation.

Objective: We examined relations between dietary patterns and markers of inflammation and endothelial activation.

Design: At baseline, diet (food-frequency questionnaire) and concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), homocysteine, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E selectin were assessed in 5089 nondiabetic participants in the Multi-Ethnic Study of Atherosclerosis.

Results: Four dietary patterns were derived by using factor analysis. The fats and processed meats pattern (fats, oils, processed meats, fried potatoes, salty snacks, and desserts) was positively associated with CRP (P for trend < 0.001), IL-6 (P for trend < 0.001), and homocysteine (P for trend = 0.002). The beans, tomatoes, and refined grains pattern (beans, tomatoes, refined grains, and high-fat dairy products) was positively related to sICAM-1 (P for trend = 0.007). In contrast, the whole grains and fruit pattern (whole grains, fruit, nuts, and green leafy vegetables) was inversely associated with CRP, IL-6, homocysteine (P for trend 0.001), and sICAM-1 (P for trend = 0.034), and the vegetables and fish pattern (fish and dark-yellow, cruciferous, and other vegetables) was inversely related to IL-6 (P for trend = 0.009). CRP, IL-6, and homocysteine relations across the fats and processed meats and whole grains and fruit patterns were independent of demographics and lifestyle factors and were not modified by race-ethnicity. CRP and homocysteine relations were independent of waist circumference.

Conclusions: These results corroborate previous findings that empirically derived dietary patterns are associated with inflammation and show that these relations in an ethnically diverse population with unique dietary habits are similar to findings in more homogeneous populations.

Key Words: Multi-Ethnic Study of Atherosclerosis • inflammation • endothelial activation • dietary patterns • factor analysis

This article has been cited by other articles:

				A. H. Auchincloss, A. V. D. Roux, M. S. Mujahid, M. Shen, A. G. Bertoni, and M. R. Carnethon Neighborhood Resources for Physical Activity and Healthy Foods and Incidence of Type 2 Diabetes Mellitus: The Multi-Ethnic Study of Atherosclerosis Arch Intern Med, October 12, 2009; 169(18): 1698 - 1704. [Abstract] [Full Text] [PDF]

				J. A Nettleton, J. F Polak, R. Tracy, G. L Burke, and D. R Jacobs Jr Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis Am. J. Clinical Nutrition, September 1, 2009; 90(3): 647 - 654. [Abstract] [Full Text] [PDF]

				L. V. Moore, A. V. Diez Roux, J. A. Nettleton, D. R. Jacobs, and M. Franco Fast-Food Consumption, Diet Quality, and Neighborhood Exposure to Fast Food: The Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., July 1, 2009; 170(1): 29 - 36. [Abstract] [Full Text] [PDF]

				A. Zulli, E. Lau, B. P.P. Wijaya, X. Jin, K. Sutarga, G. D. Schwartz, J. Learmont, P. J. Wookey, A. Zinellu, C. Carru, et al. High Dietary Taurine Reduces Apoptosis and Atherosclerosis in the Left Main Coronary Artery: Association With Reduced CCAAT/Enhancer Binding Protein Homologous Protein and Total Plasma Homocysteine but not Lipidemia Hypertension, June 1, 2009; 53(6): 1017 - 1022. [Abstract] [Full Text] [PDF]

				E. Ros Nuts and novel biomarkers of cardiovascular disease Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1649S - 1656S. [Abstract] [Full Text] [PDF]

				J. A. Nettleton, P. L. Lutsey, Y. Wang, J. A. Lima, E. D. Michos, and D. R. Jacobs Jr. Diet Soda Intake and Risk of Incident Metabolic Syndrome and Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) Diabetes Care, April 1, 2009; 32(4): 688 - 694. [Abstract] [Full Text] [PDF]

				M. Franco, A. V Diez-Roux, J. A Nettleton, M. Lazo, F. Brancati, B. Caballero, T. Glass, and L. V Moore Availability of healthy foods and dietary patterns: the Multi-Ethnic Study of Atherosclerosis Am. J. Clinical Nutrition, March 1, 2009; 89(3): 897 - 904. [Abstract] [Full Text] [PDF]

				D. R Jacobs Jr, D. Sluik, M. H Rokling-Andersen, S. A Anderssen, and C. A Drevon Association of 1-y changes in diet pattern with cardiovascular disease risk factors and adipokines: results from the 1-y randomized Oslo Diet and Exercise Study Am. J. Clinical Nutrition, February 1, 2009; 89(2): 509 - 517. [Abstract] [Full Text] [PDF]

				H. Chung, J. A. Nettleton, R. N. Lemaitre, R. G. Barr, M. Y. Tsai, R. P. Tracy, and D. S. Siscovick Frequency and Type of Seafood Consumed Influence Plasma (n-3) Fatty Acid Concentrations J. Nutr., December 1, 2008; 138(12): 2422 - 2427. [Abstract] [Full Text] [PDF]

				R. Iqbal, S. Anand, S. Ounpuu, S. Islam, X. Zhang, S. Rangarajan, J. Chifamba, A. Al-Hinai, M. Keltai, S. Yusuf, et al. Dietary Patterns and the Risk of Acute Myocardial Infarction in 52 Countries: Results of the INTERHEART Study Circulation, November 4, 2008; 118(19): 1929 - 1937. [Abstract] [Full Text] [PDF]

				J. A Nettleton, A. Diez-Roux, N. S Jenny, A. L Fitzpatrick, and D. R Jacobs Jr Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA) Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1405 - 1412. [Abstract] [Full Text] [PDF]

				J. A. Nettleton, L. M. Steffen, H. Ni, K. Liu, and D. R. Jacobs Jr. Dietary Patterns and Risk of Incident Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) Diabetes Care, September 1, 2008; 31(9): 1777 - 1782. [Abstract] [Full Text] [PDF]

				L Kalra, E Iveson, C Rambaran, R Sherwood, P Chowienczyk, J Ritter, A Shah, and T Forrester Homocysteine, migration and early vascular impairment in people of African descent Heart, September 1, 2008; 94(9): 1171 - 1174. [Abstract] [Full Text] [PDF]

				J. A Nettleton, M. B Schulze, R. Jiang, N. S Jenny, G. L Burke, and D. R Jacobs Jr A priori-defined dietary patterns and markers of cardiovascular disease risk in the Multi-Ethnic Study of Atherosclerosis (MESA) Am. J. Clinical Nutrition, July 1, 2008; 88(1): 185 - 194. [Abstract] [Full Text] [PDF]

				A. Nanri, D. Yoshida, T. Yamaji, T. Mizoue, R. Takayanagi, and S. Kono Dietary patterns and C-reactive protein in Japanese men and women Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1488 - 1496. [Abstract] [Full Text] [PDF]

				L. V. Moore, A. V. Diez Roux, J. A. Nettleton, and D. R. Jacobs Jr Associations of the Local Food Environment with Diet Quality--A Comparison of Assessments based on Surveys and Geographic Information Systems: The Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., April 15, 2008; 167(8): 917 - 924. [Abstract] [Full Text] [PDF]

				A. V. Diez Roux, A. H. Auchincloss, T. G. Franklin, T. Raghunathan, R. G. Barr, J. Kaufman, B. Astor, and J. Keeler Long-term Exposure to Ambient Particulate Matter and Prevalence of Subclinical Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., March 15, 2008; 167(6): 667 - 675. [Abstract] [Full Text] [PDF]

				S. A. McNaughton, K. Ball, G. D. Mishra, and D. A. Crawford Dietary Patterns of Adolescents and Risk of Obesity and Hypertension J. Nutr., February 1, 2008; 138(2): 364 - 370. [Abstract] [Full Text] [PDF]

				J. A Nettleton, L. M Steffen, M. B Schulze, N. S Jenny, R G. Barr, A. G Bertoni, and D. R Jacobs Jr Associations between markers of subclinical atherosclerosis and dietary patterns derived by principal components analysis and reduced rank regression in the Multi-Ethnic Study of Atherosclerosis (MESA) Am. J. Clinical Nutrition, June 1, 2007; 85(6): 1615 - 1625. [Abstract] [Full Text] [PDF]

				A. Esmaillzadeh, M. Kimiagar, Y. Mehrabi, L. Azadbakht, F. B. Hu, and W. C. Willett Dietary Patterns and Markers of Systemic Inflammation among Iranian Women J. Nutr., April 1, 2007; 137(4): 992 - 998. [Abstract] [Full Text] [PDF]