AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wärnberg, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wärnberg, J.
Agricola
Right arrow Articles by Wärnberg, J.
American Journal of Clinical Nutrition, Vol. 84, No. 3, 505-512, September 2006
© 2006 American Society for Nutrition


ORIGINAL RESEARCH COMMUNICATION

Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study1,2,3

Julia Wärnberg, Esther Nova, Luis A Moreno, Javier Romeo, Maria I Mesana, Jonatan R Ruiz, Francisco B Ortega, Michael Sjöström, Manuel Bueno, Ascensión Marcos and the AVENA Study group

1 From the Immunonutrition Group, Department of Metabolism and Nutrition, Consejo Superior de Investigaciones Científicas, Madrid, Spain (JW, EN, JR and AM); the Unit for Preventive Nutrition, Department of Biosciences and Nutrition, NOVUM, Karolinska Institutet, Stockholm, Sweden (JW, JRR, FBO, and MS); the Escuela Universitaria Ciencias de la Salud, University of Zaragoza, Spain (LAM, MIM and MB); and the Department of Physiology, School of Medicine, University of Granada, Spain (JRR and FBO)

Background: In adults, obesity is characterized by a state of chronic low-grade inflammation accompanied by moderately high concentrations of acute phase inflammatory proteins. Recent results regarding C-reactive protein (CRP) point to a similar status in adolescents; however, studies of associations of the serum inflammatory proteins CRP, ceruloplasmin, and complement factors C3 and C4 with body fat distribution remain scarce.

Objective: We aimed to establish the possible relations of serum inflammatory proteins with body fat estimates and body fat distribution in an apparently healthy adolescent population.

Design: This report included 472 adolescents (248 males and 224 females) aged 13–18.5 y who were recruited from the Spanish cross-sectional multicenter AVENA Study for whom anthropometric and immunologic data were complete. The concentrations of the serum proteins and the in vitro production of cytokines (interleukin 6 and tumor necrosis factor {alpha}) by isolated and stimulated white blood cells were measured. Relations with anthropometric measurements were explored by using simple and partial correlations.

Results: CRP, C3, and C4 were correlated with central obesity (as measured by waist circumference) and total body fat in both sexes (P < 0.01) and with ceruloplasmin in females only. After further adjustment for BMI, C3 remained independently associated with central obesity (P < 0.05). Production of the cytokines by white blood cells did not seem to be affected by an excess of body fat.

Conclusions: Total body fat seems to be associated with a chronic low-grade systemic inflammation in apparently healthy adolescents. Central obesity is independently associated with C3 concentrations, which makes this marker especially interesting for further studies of obesity-related diseases.

Key Words: Adolescents • inflammation • complement factors • C-reactive protein • CRP • central obesity




This article has been cited by other articles:


Home page
Eur Heart JHome page
T. S.M. Tsang, M. E. Barnes, Y. Miyasaka, S. S. Cha, K. R. Bailey, G. C. Verzosa, J. B. Seward, and B. J. Gersh
Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years
Eur. Heart J., September 2, 2008; 29(18): 2227 - 2233.
[Abstract] [Full Text] [PDF]


Home page
Arch Pediatr Adolesc MedHome page
J. R. Ruiz, F. B. Ortega, J. Warnberg, L. A. Moreno, J. J. Carrero, M. Gonzalez-Gross, A. Marcos, A. Gutierrez, and M. Sjostrom
Inflammatory Proteins and Muscle Strength in Adolescents: The AVENA Study
Arch Pediatr Adolesc Med, May 1, 2008; 162(5): 462 - 468.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by The American Society for Nutrition