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ORIGINAL RESEARCH COMMUNICATION |
1 From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA (AAL, NPL, KGT, CAC, STW, and DRG); the Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, MA (AAL); the Division of Pediatric Pulmonary Medicine (NPL) and the Department of Emergency Medicine (CAC), Massachusetts General Hospital, Boston, MA; the Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA (SLR-S, JWR-E, and MWG); the Department of Nutrition, Harvard School of Public Health, Boston, MA (MWG); and the Harvard Medical School, Boston, MA (AAL, NPL, KGT, CAC, STW, and DRG)
Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy.
Objective: We investigated the association of maternal total intakes (foods + supplements) of 10 antioxidant nutrients during pregnancy with wheezing and eczema in 2-y-old children.
Design: Subjects were 1290 mother-child pairs in an ongoing cohort study. Maternal dietary and supplement intakes were assessed by using a validated food-frequency questionnaire administered in the first and second trimesters. Antioxidant nutrient intakes were calculated, and the mean for each nutrient was considered to be the exposure during pregnancy. The outcomes of interest were any wheezing by the child during either the first or second year of life, recurrent wheezing in both years, and eczema in either the first or second year.
Results: No association was observed between maternal total intake of any antioxidant nutrient and eczema. In multivariate logistic regression models, the highest quartile compared with the lowest quartile of maternal total intakes of vitamin E [odds ratio (OR): 0.70; 95% CI: 0.48, 1.03] and zinc (OR: 0.59; 95% CI: 0.41, 0.88) was inversely associated with any wheezing at 2 y of age (P for trend = 0.06 and 0.01 over quartiles of intake for vitamin E and zinc, respectively). Similar results were obtained for recurrent wheezing at 2 y of age with vitamin E (OR: 0.49; 95% CI: 0.27, 0.90) and zinc (OR: 0.49; 95% CI: 0.27, 0.87) (P for trend = 0.05 and 0.06 over quartiles of intake for vitamin E and zinc, respectively).
Conclusion: Our results suggest that higher maternal total intakes of antioxidants during pregnancy may decrease the risks for wheezing illnesses in early childhood.
Key Words: Asthma • diet • antioxidants • eczema • childhood wheezing
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