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American Journal of Clinical Nutrition, Vol. 84, No. 4, 912-919, October 2006
© 2006 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins1,2,3

Lian Zhang, Mitchell H Gail, Yu-que Wang, Linda Morris Brown, Kai-feng Pan, Jun-ling Ma, Harunobu Amagase, Wei-cheng You and Roxana Moslehi

1 From the Beijing Institute for Cancer Research, Beijng, China (LZ, YW, KP, JM, and WY); the Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (MHG, LMB, and RM); and Wakunaga of America Co Ltd, Mission Viejo, CA (HA)

Background: Little is known about the long-term effects of garlic or micronutrient supplementation on total, HDL, and LDL cholesterol in disease-free persons.

Objective: We aimed to assess the effects of long-term supplementation with garlic and micronutrients and of short-term amoxicillin and omeprazole treatment on serum total, HDL, and LDL cholesterol in a rural Chinese population.

Design: We conducted a randomized, double-blind, placebo-controlled, 2 x 2 x 2 and 2 x 2 factorial study of precancerous gastric lesions in 3411 subjects in Linqu County, Shandong Province, China. Thirty-four subjects were randomly selected from each of 12 treatment strata. Sera were analyzed at 3.3 and 7.3 y to measure effects on total, HDL, and LDL cholesterol after 2-wk twice-daily treatment with 1 g amoxicillin and 20 mg omeprazole and supplementation throughout the study with 1) 2 capsules twice daily, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, or 2) twice-daily micronutrient capsules containing 250 mg vitamin C, 100 IU vitamin E, and 37.5 mg selenium.

Results: Regressions adjusted for covariates indicated increases of 0.22 mmol total cholesterol/L (P = 0.01) and 0.19 mmol LDL/L (P = 0.02) after 7.3 y of micronutrient supplementation, but no effect of garlic supplementation or short-term amoxicillin and omeprazole treatment.

Conclusions: In this rural Chinese population with low meat intake and moderate cholesterol concentrations, long-term garlic supplementation had no effect on lipid profiles, whereas micronutrient supplementation was associated with small but significant increases in total and LDL-cholesterol concentrations at 7.3 y.

Key Words: Cholesterol • blood lipids • garlic supplementation • vitamin supplementation • cardiovascular disease • Helicobacter pylori antibiotic therapy • China






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