HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koo, W. W. Articles by Hockman, E. M Search for Related Content PubMed PubMed Citation Articles by Koo, W. W. Articles by Hockman, E. M Agricola Articles by Koo, W. W. Articles by Hockman, E. M

Posthospital discharge feeding for preterm infants: effects of standard compared with enriched milk formula on growth, bone mass, and body composition^1,2,3

¹ From The Carman and Ann Adams Department of Pediatrics, Wayne State University and Hutzel Hospital (WWKK), and Computing and Information Technology, Wayne State University (EMH), Detroit, MI

Background: Despite the theoretical benefits of nutrient-enriched formula given to preterm infants after hospital discharge, its role in reversing growth deficits after hospital discharge remains poorly defined.

Objective: The aim was to determine the effect of different formulas on the growth, bone mass, and body composition of preterm infants after hospital discharge.

Design: This was a randomized, double blind comparison of a nutrient-enriched formula (EF) and a formula for term infants (TF) given for 1 y after hospital discharge. Compared with the TF, the EF had a higher energy density and higher contents of protein, calcium, and phosphorus (by 10%, 21%, 44%, and 11%, respectively) and higher contents of almost all other nutrients (by 10%).

Results: Birth weights of the infants were 630–1620 g (median: 1250 g) and gestational ages were 24–34 wk (median: 29 wk). TF resulted in significantly greater weight, length, head circumference measurements, and their respective z scores on the basis of age- and sex-specific norms. At the end of the study, the mean z scores for the corrected age of infants in the TF group were –0.37 for weight, 0.001 for length, and 0.50 for head circumference. The TF group also had significantly greater dual-energy X-ray absorptiometry measured bone and lean and fat mass than did the EF group (P < 0.05 for all comparisons).

Conclusions: The use of EF for preterm infants after hospital discharge shows no advantage over TF in growth, bone mineralization, and body composition. More studies are needed to determine the optimal postdischarge nutrition support for preterm infants.

Key Words: Nutrition support • dual-energy X-ray absorptiometry • infants • bone • lean • fat

This article has been cited by other articles:

				D. L. O'Connor, S. Khan, K. Weishuhn, J. Vaughan, A. Jefferies, D. M. Campbell, E. Asztalos, M. Feldman, J. Rovet, C. Westall, et al. Growth and Nutrient Intakes of Human Milk-Fed Preterm Infants Provided With Extra Energy and Nutrients After Hospital Discharge Pediatrics, April 1, 2008; 121(4): 766 - 776. [Abstract] [Full Text] [PDF]

				W. C. Heird Progress in Promoting Breast-Feeding, Combating Malnutrition, and Composition and Use of Infant Formula, 1981-2006 J. Nutr., February 1, 2007; 137(2): 499S - 502S. [Abstract] [Full Text] [PDF]