HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lê, K.-A. Articles by Tappy, L. Search for Related Content PubMed PubMed Citation Articles by Lê, K.-A. Articles by Tappy, L. Agricola Articles by Lê, K.-A. Articles by Tappy, L.

A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans ^1,2,3,4

¹ From the Department of Physiology, University of Lausanne, Lausanne, Switzerland (K-AL, DF, RS, and LT); the University Institute of Social and Preventive Medicine, Lausanne, Switzerland (DF); the Department of Clinical Research, MR Spectroscopy and Methodology, University of Bern, Bern, Switzerland (MI, RK, PV, and CB); the Pennington Biomedical Research Center, Baton Rouge, LA (ER); and the Division of Diabetes, Endocrinology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland (LT)

Background: High fructose consumption is suspected to be causally linked to the epidemics of obesity and metabolic disorders. In rodents, fructose leads to insulin resistance and ectopic lipid deposition. In humans, the effects of fructose on insulin sensitivity remain debated, whereas its effect on ectopic lipids has never been investigated.

Objective: We assessed the effect of moderate fructose supplementation on insulin sensitivity (IS) and ectopic lipids in healthy male volunteers (n = 7).

Design: IS, intrahepatocellular lipids (IHCL), and intramyocellular lipids (IMCL) were measured before and after 1 and 4 wk of a high-fructose diet containing 1.5 g fructose · kg body wt^–1 · d^–1. Adipose tissue IS was evaluated from nonesterified fatty acid suppression, hepatic IS from suppression of hepatic glucose output (6,6-²H₂-glucose), and muscle IS from the whole-body glucose disposal rate during a 2-step hyperinsulinemic euglycemic clamp. IHCL and IMCL were measured by ¹H magnetic resonance spectroscopy.

Results: Fructose caused significant (P < 0.05) increases in fasting plasma concentrations of triacylglycerol (36%), VLDL-triacylglycerol (72%), lactate (49%), glucose (5.5%), and leptin (48%) without any significant changes in body weight, IHCL, IMCL, or IS. IHCL were negatively correlated with triacylglycerol after 4 wk of the high-fructose diet (r = –0.78, P < 0.05).

Conclusion: Moderate fructose supplementation over 4 wk increases plasma triacylglycerol and glucose concentrations without causing ectopic lipid deposition or insulin resistance in healthy humans.

Key Words: Cardiovascular disease risk • dyslipidemia • healthy men • ectopic lipids • insulin sensitivity • fructose

This article has been cited by other articles:

				M. Bortolotti, R. Kreis, C. Debard, B. Cariou, D. Faeh, M. Chetiveaux, M. Ith, P. Vermathen, N. Stefanoni, K.-A. Le, et al. High protein intake reduces intrahepatocellular lipid deposition in humans Am. J. Clinical Nutrition, October 1, 2009; 90(4): 1002 - 1010. [Abstract] [Full Text] [PDF]

				J. L. Sievenpiper, A. J. Carleton, S. Chatha, H. Y. Jiang, R. J. de Souza, J. Beyene, C. W.C. Kendall, and D. J.A. Jenkins Heterogeneous Effects of Fructose on Blood Lipids in Individuals With Type 2 Diabetes: Systematic review and meta-analysis of experimental trials in humans Diabetes Care, October 1, 2009; 32(10): 1930 - 1937. [Abstract] [Full Text] [PDF]

				K.-A. Le, M. Ith, R. Kreis, D. Faeh, M. Bortolotti, C. Tran, C. Boesch, and L. Tappy Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1760 - 1765. [Abstract] [Full Text] [PDF]

				G. Livesey Fructose Ingestion: Dose-Dependent Responses in Health Research J. Nutr., June 1, 2009; 139(6): 1246S - 1252S. [Abstract] [Full Text] [PDF]

				E. J. Schaefer, J. A. Gleason, and M. L. Dansinger Dietary Fructose and Glucose Differentially Affect Lipid and Glucose Homeostasis J. Nutr., June 1, 2009; 139(6): 1257S - 1262S. [Abstract] [Full Text] [PDF]

				T. J. Angelopoulos, J. Lowndes, L. Zukley, K. J. Melanson, V. Nguyen, A. Huffman, and J. M. Rippe The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid J. Nutr., June 1, 2009; 139(6): 1242S - 1245S. [Abstract] [Full Text] [PDF]

				K. L. Stanhope and P. J. Havel Fructose Consumption: Considerations for Future Research on Its Effects on Adipose Distribution, Lipid Metabolism, and Insulin Sensitivity in Humans J. Nutr., June 1, 2009; 139(6): 1236S - 1241S. [Abstract] [Full Text] [PDF]

				R. J. Johnson, S. E. Perez-Pozo, Y. Y. Sautin, J. Manitius, L. G. Sanchez-Lozada, D. I. Feig, M. Shafiu, M. Segal, R. J. Glassock, M. Shimada, et al. Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocr. Rev., February 1, 2009; 30(1): 96 - 116. [Abstract] [Full Text] [PDF]

				K. J Melanson, T. J Angelopoulos, V. Nguyen, L. Zukley, J. Lowndes, and J. M Rippe High-fructose corn syrup, energy intake, and appetite regulation Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1738S - 1744S. [Abstract] [Full Text] [PDF]

				N. Stefan, K. Kantartzis, and H.-U. Haring Causes and Metabolic Consequences of Fatty Liver Endocr. Rev., December 1, 2008; 29(7): 939 - 960. [Abstract] [Full Text] [PDF]

				G. Livesey and R. Taylor Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1419 - 1437. [Abstract] [Full Text] [PDF]

				A. Shapiro, W. Mu, C. Roncal, K.-Y. Cheng, R. J. Johnson, and P. J. Scarpace Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1370 - R1375. [Abstract] [Full Text] [PDF]

				E. J. Parks, L. E. Skokan, M. T. Timlin, and C. S. Dingfelder Dietary Sugars Stimulate Fatty Acid Synthesis in Adults J. Nutr., June 1, 2008; 138(6): 1039 - 1046. [Abstract] [Full Text] [PDF]

				K. L Stanhope, S. C Griffen, B. R Bair, M. M Swarbrick, N. L Keim, and P. J Havel Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1194 - 1203. [Abstract] [Full Text] [PDF]

				A. Kotronen and H. Yki-Jarvinen Fatty Liver: A Novel Component of the Metabolic Syndrome Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 27 - 38. [Abstract] [Full Text] [PDF]

				S. Reungjui, C. A. Roncal, W. Mu, T. R. Srinivas, D. Sirivongs, R. J. Johnson, and T. Nakagawa Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2724 - 2731. [Abstract] [Full Text] [PDF]