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ORIGINAL RESEARCH COMMUNICATION |
1 From the Departments of Nutritional Sciences (KFH, PMK-E, and KDH) and Biobehavioral Health (SGW) and The Huck Institutes of the Life Sciences (KFH), Pennsylvania State University, University Park, PA; Frito-Lay, Inc, Plano, TX (KDH); and the Lipid and Lipoprotein Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (NMS and PA)
Background: Plasma lipoproteins may be classified by their apolipoprotein composition. The lipoprotein subclass containing apolipoproteins B and C (LpB:C) is considered the most atherogenic.
Objective: We evaluated the acute effects of individual fatty acids on apolipoprotein B (apo B)–containing lipoproteins in adults with type 2 diabetes (n = 15).
Design: We administered 3 meals in a randomized, double-blind, crossover design. Treatments contained skim milk and 50 g fat from high–oleic acid safflower and canola oils (monounsaturated fatty acid; MUFA), MUFA + 3.5 g 
-linolenic acid (ALA; MUFA + ALA) from high-ALA canola oil, or MUFA + 4.0 g both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA; MUFA + EPA/DHA) from sardine oil. Apo B, LpB, LpB:C, LpB:E + LpB:C:E, and LpA-II:B:C:D:E were measured at baseline and 2 and 4 h after the meal. Flow-mediated dilation was measured at baseline and 4 h after the meal.
Results: The treatments significantly increased apo B and LpB postprandially (P < 0.03 for both), but the magnitude of the changes did not differ significantly between the treatments. The postprandial change in LpB:C was 23% lower after MUFA + EPA/DHA than after MUFA (treatment x time interaction, P < 0.0001). MUFA + ALA attenuated the increase in LpA-II:B:C:D:E in those with high triacylglycerols (
1.69 mmol/L) but was the only treatment to significantly increase this particle in those with low triacylglycerols (treatment x group interaction, P < 0.0001). Examination of change scores did not reveal the source of the interaction of treatment and time (P < 0.007) for LpB:E + LpB:C:E. Furthermore, the subjects with the largest increases in LpB:C exhibited the largest impairment in endothelial function.
Conclusions: The results suggest that unsaturated fatty acids differentially affect concentrations of apo B–containing lipoprotein subclasses. A rise in LpB:C adversely affects endothelial function. Meals containing MUFA + EPA/DHA attenuated the postprandial rise in LpB:C and the impairment of endothelial function.
Key Words: Lipoproteins • apolipoprotein B • type 2 diabetes • hypertriglyceridemia • n–3 fatty acids • monounsaturated fatty acids • lipoproteins LpB:C • postprandial apolipoproteins
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