| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Rollins School of Public Health, Emory University, Atlanta, GA (ADS); the Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA (HSK); the Mailman School of Public Health, Columbia University, New York, NY (AR, PAZ, and LHL); and TNO Quality of Life, Leiden, Netherlands (KvdP)
Background: Few studies in humans have related maternal undernutrition to the size of the adult offspring.
Objective: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944–1945 were related to offspring length, weight, and indexes of adiposity in middle age.
Design: We recruited 1) exposed persons born in western Netherlands between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 2) unexposed persons born in the same 3 institutions during 1943 or 1947 whose mothers did not experience famine during this pregnancy, and 3) unexposed same-sex siblings of persons in series 1 or 2. Anthropometric measurements (n = 427 males and 529 females) were obtained between 2003 and 2005. We defined 4 windows of gestational exposure (by ordinal weeks 1–10, 11–20, 21–30, and 31 through delivery) on the basis of exposure to a ration of <900 kcal/d during the whole 10-wk interval.
Results: Exposure to reduced rations was associated with increased weight and greater indexes of fat deposition at several tissue sites in women but not in men (P for interaction <0.01). Measures of length and linear proportion were not associated with exposure to famine.
Conclusion: Reduced food availability may lead to increased adiposity later in life in female offspring.
Key Words: Anthropometric measures • body composition • body mass index • body size • famine • maternal and infant health • Netherlands • nutrition • obesity
This article has been cited by other articles:
|
|
 |
|
  E. W. Tobi, L.H. Lumey, R. P. Talens, D. Kremer, H. Putter, A. D. Stein, P. E. Slagboom, and B. T. Heijmans DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific Hum. Mol. Genet., November 1, 2009; 18(21): 4046 - 4053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Stein, A. Rundle, N. Wada, R. A. Goldbohm, and L. H. Lumey Associations of Gestational Exposure to Famine with Energy Balance and Macronutrient Density of the Diet at Age 58 Years Differ According to the Reference Population Used J. Nutr., August 1, 2009; 139(8): 1555 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lumey, A. D Stein, H. S Kahn, and J. Romijn Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1737 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S Kahn, M. Graff, A. D Stein, and L H Lumey A fingerprint marker from early gestation associated with diabetes in middle age: The Dutch Hunger Winter Families Study Int. J. Epidemiol., February 1, 2009; 38(1): 101 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hawkesworth, A. M. Prentice, A. J. C. Fulford, and S. E. Moore Dietary Supplementation of Rural Gambian Women during Pregnancy Does Not Affect Body Composition in Offspring at 11-17 Years of Age J. Nutr., December 1, 2008; 138(12): 2468 - 2473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Meas, S. Deghmoun, P. Armoogum, C. Alberti, and C. Levy-Marchal Consequences of Being Born Small for Gestational Age on Body Composition: An 8-Year Follow-Up Study J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3804 - 3809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Griffin, H. Kramer, and A. K. Bidani Adverse renal consequences of obesity Am J Physiol Renal Physiol, April 1, 2008; 294(4): F685 - F696. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
