HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chong, M. F-F Articles by Frayn, K. N Search for Related Content PubMed PubMed Citation Articles by Chong, M. F-F Articles by Frayn, K. N Agricola Articles by Chong, M. F-F Articles by Frayn, K. N

Mechanisms for the acute effect of fructose on postprandial lipemia^1,2,3

¹ From the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

Background: A high fructose intake can lead to postprandial hypertriacylglycerolemia. The underlying mechanism is unclear.

Objective: The objective of the study was to investigate the mechanisms involved in fructose-induced hypertriacylglycerolemia and the contribution of de novo lipogenesis in an acute setting.

Design: In a randomized, crossover study, 14 subjects were given a fructose or glucose test meal after an overnight fast. [²H₂]Palmitate and [U¹³C]D-fructose or [U¹³C]D-glucose were added to trace the handling of dietary fats and the fate of dietary sugars in the body. Blood samples were taken before and after the meal. Respiratory exchange ratio was measured by using indirect calorimetry, and breath samples were collected.

Results: Plasma triacylglycerol and VLDL-triacylglycerol concentrations were significantly higher (P = 0.001 for both), whereas the concentrations of insulin and [²H₂]palmitate in nonesterified fatty acids were significantly lower after fructose than after glucose (P = 0.002 and 0.03, respectively). The respiratory exchange ratio was higher after fructose (P = 0.04); significantly (P = 0.003) more carbon from sugars was recovered in breath carbon dioxide over 6 h after fructose (30.5%) than after glucose (24.5%). At 240 min, newly synthesized fatty acids from fructose made up 0.4% of circulating VLDL-triacylglycerol, whereas newly synthesized triacylglycerol-glycerol made up 38%. Newly synthesized fatty acids and triacylglycerol-glycerol from glucose contributed almost none of VLDL-triacylglycerol (P = 0.002 and 0.007 for glucose and fructose, respectively).

Conclusions: The lower insulin excursion after fructose may result in less activation of adipose tissue lipoprotein lipase, which led to impaired triacylglycerol clearance. The contribution of de novo lipogenesis to fructose-induced hypertriacylglycerolemia is small, but its effect on altering the partitioning of fatty acids toward esterification may be considerable.

Key Words: Fructose • hypertriglyceridemia • de novo lipogenesis • mechanisms • high-carbohydrate diets • stable isotopes • lipoprotein lipase • carbohydrate oxidation

This article has been cited by other articles:

				J. L. Sievenpiper, A. J. Carleton, S. Chatha, H. Y. Jiang, R. J. de Souza, J. Beyene, C. W.C. Kendall, and D. J.A. Jenkins Heterogeneous Effects of Fructose on Blood Lipids in Individuals With Type 2 Diabetes: Systematic review and meta-analysis of experimental trials in humans Diabetes Care, October 1, 2009; 32(10): 1930 - 1937. [Abstract] [Full Text] [PDF]

				R. K. Johnson, L. J. Appel, M. Brands, B. V. Howard, M. Lefevre, R. H. Lustig, F. Sacks, L. M. Steffen, J. Wylie-Rosett, and on behalf of the American Heart Association Nutrit Dietary Sugars Intake and Cardiovascular Health: A Scientific Statement From the American Heart Association Circulation, September 15, 2009; 120(11): 1011 - 1020. [Abstract] [Full Text] [PDF]

				J. J. Winnick, Z. An, M. C. Moore, C. J. Ramnanan, B. Farmer, M. Shiota, and A. D. Cherrington A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin Am J Physiol Endocrinol Metab, August 1, 2009; 297(2): E358 - E366. [Abstract] [Full Text] [PDF]

				K.-A. Le, M. Ith, R. Kreis, D. Faeh, M. Bortolotti, C. Tran, C. Boesch, and L. Tappy Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1760 - 1765. [Abstract] [Full Text] [PDF]

				H. E. C. Hanwell, C. D. Kay, J. W. Lampe, B. J. Holub, and A. M. Duncan Acute Fish Oil and Soy Isoflavone Supplementation Increase Postprandial Serum (n-3) Polyunsaturated Fatty Acids and Isoflavones but Do Not Affect Triacylglycerols or Biomarkers of Oxidative Stress in Overweight and Obese Hypertriglyceridemic Men J. Nutr., June 1, 2009; 139(6): 1128 - 1134. [Abstract] [Full Text] [PDF]

				J. P. Bantle Dietary Fructose and Metabolic Syndrome and Diabetes J. Nutr., June 1, 2009; 139(6): 1263S - 1268S. [Abstract] [Full Text] [PDF]

				E. J. Schaefer, J. A. Gleason, and M. L. Dansinger Dietary Fructose and Glucose Differentially Affect Lipid and Glucose Homeostasis J. Nutr., June 1, 2009; 139(6): 1257S - 1262S. [Abstract] [Full Text] [PDF]

				K. L. Teff, J. Grudziak, R. R. Townsend, T. N. Dunn, R. W. Grant, S. H. Adams, N. L. Keim, B. P. Cummings, K. L. Stanhope, and P. J. Havel Endocrine and Metabolic Effects of Consuming Fructose- and Glucose-Sweetened Beverages with Meals in Obese Men and Women: Influence of Insulin Resistance on Plasma Triglyceride Responses J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1562 - 1569. [Abstract] [Full Text] [PDF]

				L. Hodson, S. E. McQuaid, F. Karpe, K. N. Frayn, and B. A. Fielding Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E64 - E71. [Abstract] [Full Text] [PDF]

				G. Livesey and R. Taylor Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1419 - 1437. [Abstract] [Full Text] [PDF]

				E. J. Parks, L. E. Skokan, M. T. Timlin, and C. S. Dingfelder Dietary Sugars Stimulate Fatty Acid Synthesis in Adults J. Nutr., June 1, 2008; 138(6): 1039 - 1046. [Abstract] [Full Text] [PDF]

				C. M. Brown, A. G. Dulloo, G. Yepuri, and J.-P. Montani Fructose ingestion acutely elevates blood pressure in healthy young humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R730 - R737. [Abstract] [Full Text] [PDF]

				L. Hodson, A. S.T. Bickerton, S. E. McQuaid, R. Roberts, F. Karpe, K. N. Frayn, and B. A. Fielding The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women: Studies in the Postprandial State Diabetes, October 1, 2007; 56(10): 2433 - 2441. [Abstract] [Full Text] [PDF]