AJCN EB Program 2010 Early Registration
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weng, F. L
Right arrow Articles by Zemel, B. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weng, F. L
Right arrow Articles by Zemel, B. S
Agricola
Right arrow Articles by Weng, F. L
Right arrow Articles by Zemel, B. S
American Journal of Clinical Nutrition, Vol. 86, No. 1, 150-158, July 2007
© 2007 American Society for Nutrition


ORIGINAL RESEARCH COMMUNICATION

Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents1,2,3

Francis L Weng, Justine Shults, Mary B Leonard, Virginia A Stallings and Babette S Zemel

1 From the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA (FLW); the Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA (FLW, JS, and MBL); and the Divisions of Nephrology (MBL) and Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA (BSZ and VAS)

Background:Serum 25-hydroxyvitamin D [25(OH)D] concentrations serve as a biomarker for vitamin D stores. Prior studies have not examined the risk factors for low vitamin D concentrations in a multiethnic sample of US youth across a broad age range.

Objective:The objective was to determine the prevalence of and factors associated with low concentrations of 25(OH)D in children and adolescents.

Design:Serum 25(OH)D concentrations were measured in 382 healthy children aged 6-21 y living in the northeastern United States. Dietary and supplemental vitamin D intake was assessed by interview. Fat and lean mass were assessed by dual-energy X-ray absorptiometry. Multivariable ordinal logistic regression was used to determine factors associated with decreased concentrations of 25(OH)D.

Results:The median concentration of 25(OH)D was 28 ng/mL (interquartile range: 19–35 ng/mL), and 55% of subjects had 25(OH)D concentrations <30 ng/mL. 25(OH)D concentrations were inversely correlated with parathyroid hormone concentrations (Spearman's r = –0.31, P < 0.001) but were not significantly correlated with 1,25-dihydroxyvitamin D concentrations. In the multivariable model, older age (P < 0.001), black race [odds ratio (OR): 14.2; 95% CI: 8.53, 23.5], wintertime study visit (OR: 3.55; 95% CI: 2.29, 5.50), and total daily vitamin D intake <200 IU (OR: 1.58; 95% CI: 1.02, 2.46) were associated with low vitamin D concentrations. Fat and lean mass were not independently associated with vitamin D status in this healthy-weight sample.

Conclusion:Low serum 25(OH)D concentrations are prevalent in otherwise healthy children and adolescents in the northeastern United States and are related to low vitamin D intake, race, and season.

Key Words: Vitamin D • 25-hydroxyvitamin D • children • adolescents • 1;25-dihydroxyvitamin D • parathyroid hormone




This article has been cited by other articles:


Home page
PediatricsHome page
J. M. Mansbach, A. A. Ginde, and C. A. Camargo Jr
Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?
Pediatrics, November 1, 2009; 124(5): 1404 - 1410.
[Abstract] [Full Text] [PDF]


Home page
AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
J. L. Lapp
Vitamin D: Bone Health and Beyond
American Journal of Lifestyle Medicine, September 1, 2009; 3(5): 386 - 393.
[Abstract] [PDF]


Home page
Am. J. Clin. Nutr.Home page
C. M Lenders, H. A Feldman, E. Von Scheven, A. Merewood, C. Sweeney, D. M Wilson, P. D. Lee, S. H Abrams, S. E Gitelman, M. S Wertz, et al.
Relation of body fat indexes to vitamin D status and deficiency among obese adolescents
Am. J. Clinical Nutrition, September 1, 2009; 90(3): 459 - 467.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
J. Kumar, P. Muntner, F. J. Kaskel, S. M. Hailpern, and M. L. Melamed
Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004
Pediatrics, September 1, 2009; 124(3): e362 - e370.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
S. Saintonge, H. Bang, and L. M. Gerber
Implications of a New Definition of Vitamin D Deficiency in a Multiracial US Adolescent Population: The National Health and Nutrition Examination Survey III
Pediatrics, March 1, 2009; 123(3): 797 - 803.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
R. Kremer, P. P. Campbell, T. Reinhardt, and V. Gilsanz
Vitamin D Status and Its Relationship to Body Fat, Final Height, and Peak Bone Mass in Young Women
J. Clin. Endocrinol. Metab., January 1, 2009; 94(1): 67 - 73.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
A. C Looker, C. M Pfeiffer, D. A Lacher, R. L Schleicher, M. F. Picciano, and E. A Yetley
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004
Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1519 - 1527.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
A. C. Bergqvist, J. I Schall, V. A Stallings, and B. S Zemel
Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet
Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1678 - 1684.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
R. P. Heaney
Vitamin D in Health and Disease
Clin. J. Am. Soc. Nephrol., September 1, 2008; 3(5): 1535 - 1541.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
B. Hintzpeter, C. Scheidt-Nave, M. J. Muller, L. Schenk, and G. B. M. Mensink
Higher Prevalence of Vitamin D Deficiency Is Associated with Immigrant Background among Children and Adolescents in Germany
J. Nutr., August 1, 2008; 138(8): 1482 - 1490.
[Abstract] [Full Text] [PDF]


Home page
Clin. Chem.Home page
S. Mark, K. Gray-Donald, E. E. Delvin, J. O'Loughlin, G. Paradis, E. Levy, and M. Lambert
Low Vitamin D Status in a Representative Sample of Youth From Quebec, Canada
Clin. Chem., August 1, 2008; 54(8): 1283 - 1289.
[Abstract] [Full Text] [PDF]


Home page
Arch Pediatr Adolesc MedHome page
A. J. Rovner and K. O. O'Brien
Hypovitaminosis D Among Healthy Children in the United States: A Review of the Current Evidence
Arch Pediatr Adolesc Med, June 1, 2008; 162(6): 513 - 519.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
A. J Rovner, V. A Stallings, J. I Schall, M. B Leonard, and B. S Zemel
Vitamin D insufficiency in children, adolescents, and young adults with cystic fibrosis despite routine oral supplementation
Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1694 - 1699.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by The American Society for Nutrition