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American Journal of Clinical Nutrition, Vol. 86, No. 2, 444-450, August 2007
© 2007 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults1,2,3

Kenneth J Mukamal, Nancy S Jenny, Russell P Tracy and David S Siscovick

1 From the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); the Departments of Pathology (NSJ and RPT) and Biochemistry (RPT), University of Vermont, Burlington, VT; and the Departments of Epidemiology and Medicine (DSS), University of Washington, Seattle, WA

Background: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain.

Objective: We determined how alcohol intake and apolipoprotein E (apo E) and IL-6 promoter (IL-6 –174G->C) polymorphisms interact for concentrations of IL-6 and SAP.

Design: In the Cardiovascular Health Study, 2454 older adults reported their intake of beer, wine, and liquor and underwent measurements of circulating IL-6 and SAP.

Results: Alcohol intake was not associated with IL-6 concentrations among apo E4-negative or IL-6C-positive participants but was positively associated among both apo E4-positive and IL-6C-negative participants (P for trend = 0.02 for both). The corresponding interactions on SAP were not significant for alcohol overall but were similar for liquor intake.

Conclusions: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Genetic heterogeneity should be considered in understanding the cardiovascular effects of alcohol intake.

Key Words: Alcohol • inflammatory markers • epidemiology






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