|
|
||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background: Whereas obesity has been associated with an increased risk of colon cancer in men, a weak or no association has been observed in women. Results for rectal cancer have also been inconsistent.
Objective: The objective was to perform a meta-analysis to summarize the available evidence from prospective studies on the associations of overall and abdominal obesity with the risk of colon and rectal cancer.
Design: We searched MEDLINE (1966–April 2007) and the references of the retrieved articles. Study-specific relative risks (RRs) were pooled by using a random-effects model.
Results: Thirty prospective studies were included in the meta-analysis of body mass index (BMI; in kg/m2). Overall, a 5-unit increase in BMI was related to an increased risk of colon cancer in both men (RR: 1.30; 95% CI: 1.25, 1.35) and women (RR: 1.12; 95% CI: 1.07, 1.18), but the association was stronger in men (P < 0.001). BMI was positively associated with rectal cancer in men (RR: 1.12; 95% CI: 1.09, 1.16) but not in women (RR: 1.03; 95% CI: 0.99, 1.08). The difference in RRs between cancer sites was statistically significant (P < 0.001 in men and P = 0.04 in women). Colon cancer risk increased with increasing waist circumference (per 10-cm increase) in both men (RR: 1.33; 95% CI: 1.19, 1.49) and women (RR: 1.16; 95% CI: 1.09, 1.23) and with increasing waist-hip ratio (per 0.1-unit increase) in both men (RR: 1.43; 95% CI: 1.19, 1.71) and women (RR: 1.20; 95% CI: 1.08, 1.33).
Conclusions: The association between obesity and colon and rectal cancer risk varies by sex and cancer site.
Key Words: Body mass index colorectal cancer meta-analysis obesity prospective studies
This article has been cited by other articles:
![]() |
R. C.M. van Kruijsdijk, E. van der Wall, and F. L.J. Visseren Obesity and Cancer: The Role of Dysfunctional Adipose Tissue Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2569 - 2578. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. V. Seeman Secondary Effects of Antipsychotics: Women at Greater Risk Than Men Schizophr Bull, September 1, 2009; 35(5): 937 - 948. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. BROZEK, S. KRIWANEK, E. BONNER, M. PETERLIK, and H. S. CROSS Mutual Associations between Malignancy, Age, Gender, and Subsite Incidence of Colorectal Cancer Anticancer Res, September 1, 2009; 29(9): 3721 - 3726. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. L. Siegel, A. Jemal, and E. M. Ward Increase in Incidence of Colorectal Cancer Among Young Men and Women in the United States Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1695 - 1698. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. L. Ashbeck, E. T. Jacobs, M. E. Martinez, E. W. Gerner, P. Lance, and P. A. Thompson Components of Metabolic Syndrome and Metachronous Colorectal Neoplasia Cancer Epidemiol. Biomarkers Prev., April 1, 2009; 18(4): 1134 - 1143. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. T. Jacobs, D. J. Ahnen, E. L. Ashbeck, J. A. Baron, E. R. Greenberg, P. Lance, D. A. Lieberman, G. McKeown-Eyssen, A. Schatzkin, P. A. Thompson, et al. Association Between Body Mass Index and Colorectal Neoplasia at Follow-Up Colonoscopy: A Pooling Study Am. J. Epidemiol., March 15, 2009; 169(6): 657 - 666. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. G Mulholland, L. J Murray, C. R Cardwell, and M. M Cantwell Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis Am. J. Clinical Nutrition, February 1, 2009; 89(2): 568 - 576. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. M. Wolpin, J. A. Meyerhardt, A. T. Chan, K. Ng, J. A. Chan, K. Wu, M. N. Pollak, E. L. Giovannucci, and C. S. Fuchs Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer J. Clin. Oncol., January 10, 2009; 27(2): 176 - 185. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Meza, J. Jeon, S. H. Moolgavkar, and E. G. Luebeck Age-specific incidence of cancer: Phases, transitions, and biological implications PNAS, October 21, 2008; 105(42): 16284 - 16289. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. G. Kaklamani, K. B. Wisinski, M. Sadim, C. Gulden, A. Do, K. Offit, J. A. Baron, H. Ahsan, C. Mantzoros, and B. Pasche Variants of the Adiponectin (ADIPOQ) and Adiponectin Receptor 1 (ADIPOR1) Genes and Colorectal Cancer Risk JAMA, October 1, 2008; 300(13): 1523 - 1531. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. M. Ochs-Balcom, M. S. Cicek, C. L. Thompson, T. C. Tucker, R. C. Elston, S. J.Plummer, G. Casey, and L. Li Association of vitamin D receptor gene variants, adiposity and colon cancer Carcinogenesis, September 1, 2008; 29(9): 1788 - 1793. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-M. Song, J. Sung, and M. Ha Obesity and Risk of Cancer in Postmenopausal Korean Women J. Clin. Oncol., July 10, 2008; 26(20): 3395 - 3402. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. N. Ealey, S. Lu, D. Lau, and M. C. Archer Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G679 - G686. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A. Moghaddam, M. Woodward, and R. Huxley Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2533 - 2547. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |