HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hansel, B. Articles by Bruckert, E. Search for Related Content PubMed PubMed Citation Articles by Hansel, B. Articles by Bruckert, E. Agricola Articles by Hansel, B. Articles by Bruckert, E.

Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia^1,2,3

¹ From the Service d'Endocrinologie-Métabolisme, AP-HP, Hôpital de la Pitié, Paris, France (BH and EB); Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 551 "Dyslipidemia and Atherosclerosis" and University Pierre and Marie Curie, Hôpital de la Pitié, Paris, France (BH, MJC, and EB); Danone Vitapole, Centre de Recherche Daniel Carasso, Nutrivaleur, Palaiseau, France (CN, FL, FT, and TL); OPTIMED, Gieres, France (YD); Service de Cardiologie, AP-HP, Centre Hospitalier Universitaire (CHU) Rangueil, Toulouse, France (JF); Service d'Endocrinologie et Nutrition, Hôpital hôtel Dieu, Nantes, France (MK); Service de Médecine Interne, CHU de Hautepierre, Strasbourg, France (J-LS); and Service Endocrinologie, Diabétologie et Maladies Métaboliques, Hôpital du Bocage, Dijon, France (BV)

Background: Plant sterol (PS)-enriched foods have been shown to reduce plasma LDL-cholesterol concentrations. In most studies, however, PSs were incorporated into food products of high fat content.

Objective: We examined the effect of daily consumption of PS-supplemented low-fat fermented milk (FM) on the plasma lipid profile and on systemic oxidative stress in hypercholesterolemic subjects.

Design: Hypercholesterolemic subjects (LDL-cholesterol concentrations 130 and 190 mg/dL; n = 194) consumed 2 low-fat portions of FM in the same meal daily for 6 wk. Subjects were randomly assigned to 2 groups: low-fat FM enriched with 0.8 g PS ester per portion or control FM. Plasma concentrations of lipids, oxidized LDL, ß-carotene, ß-sitosterol, campesterol, and high-sensitivity C-reactive protein were measured during the trial.

Results: Plasma LDL-cholesterol concentrations were reduced by 9.5% and 7.8% after 3 and 6 wk, respectively, in the 1.6-g/d PS group compared with the control group, whereas plasma triacylglycerol and HDL-cholesterol concentrations were not significantly affected. In addition, there were no significant changes in serum ß-carotene on normalization to LDL cholesterol during the study period in both groups, whereas plasma concentrations of oxidized LDL were reduced significantly in the PS group compared with the control group (–1.73 compared with 1.40 U/L, respectively; P < 0.05). Plasma sitosterol concentrations were increased by 35% (P < 0.001 compared with control); however, campesterol concentrations did not change during the study period.

Conclusion: Daily consumption of 1.6 g PS in low-fat FM efficiently lowers LDL cholesterol in subjects with moderate hypercholesterolemia without deleterious effects on biomarkers of oxidative stress.

Key Words: Plant sterol • hypercholesterolemia • oxidative stress • oxidized LDL • ß-carotene