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Insulin, insulin-like growth factors, insulin resistance, and neoplasia^1,2,3,4

¹ From the Department of Oncology, McGill University and Jewish General Hospital, Montréal, Quebec, Canada

ABSTRACT

An accumulating body of epidemiologic and laboratory evidence suggests that insulin and insulin-like growth factors influence both the risk and the prognosis of cancer. In this brief review, I highlight topics covered in my lecture on research directions in this field, including the view that metformin deserves investigation as a potential adjunct in the treatment or prevention of cancer in persons with hyperinsulinemia.

Key Words: Insulin • insulin-like growth factor-I • IGF-I • metformin • risk • prevention • treatment

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