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American Journal of Clinical Nutrition, Vol. 86, No. 3, 872S-877S, September 2007
© 2007 American Society for Nutrition

Metabolic Syndrome and the Onset of Cancer

Epigenetic modulation and cancer: effect of metabolic syndrome?1,2,3

Sharon A Ross and John A Milner

1 From the Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD

ABSTRACT

The importance of epigenetics in the etiology of disease, including cancer development and progression, is increasingly being recognized. However, the relevance of epigenetics to the metabolic syndrome, and how it may affect cancer, is only beginning to capture the interest of the scientific community. This review focuses on data supporting the hypothesis that, in addition to the "thrifty genotype" and "thrifty phenotype" hypotheses, diet-induced changes in "epigenetic programming" during fetal and postnatal development may precipitate the metabolic syndrome. Thus, epigenetics may bridge both the thrifty genotype and thrifty phenotype hypotheses and provide a link between genes and the environment concerning disease predisposition to metabolic syndrome and its associated diseases.

Key Words: Epigenetics • cancer • nutrition • maternal diet • metabolic syndrome




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[Abstract] [Full Text] [PDF]


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