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Effect of the interaction between the fatty acid–binding protein 2 gene Ala54Thr polymorphism and dietary fatty acids on peripheral insulin sensitivity: a cross-sectional study^1,2,3

¹ From the Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya (Red de Diabetes y Metabolismo of the Instituto de Salud Carlos III, Madrid), Málaga, Spain (SM, GR-M, MCA, MSRdA, IE, IC, and FS), and the Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Victoria, Málaga, and Centro de Investigación Biomédica En Red de Fisiopatología de la Obesidad y Nutrición CB06/03 of the Instituto de Salud Carlos III, Madrid (FC)

Background: The intestinal fatty acid–binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids and may affect insulin sensitivity and glucose metabolism.

Objective: The objective was to study the effect of interaction between the Ala54Thr polymorphism of the FABP2 gene (FABP2) and the type of dietary cooking oil used on peripheral insulin sensitivity in a population from southern Spain.

Design: The study was cross-sectional. Anthropometric measurements were obtained for 1226 persons aged 18–65 y selected randomly from the municipal census of Pizarra, Spain. An oral-glucose-tolerance test was given to 1020 of these persons. Insulin resistance was measured by homeostasis model assessment. Samples of the cooking oil being used were taken from the kitchens of a random subset of 538 persons.

Results: Persons who consumed sunflower oil and who also had the Thr54 variant had higher insulin resistance than did those who consumed olive oil (P = 0.01). We detected an interaction between the Ala54Thr polymorphism and the type of oil consumed that accounted for the variance in insulin resistance (P = 0.02).

Conclusions: The effect of dietary fatty acids on the populational pattern of insulin resistance is not independent of the Ala54Thr polymorphism of FABP2. An interaction existed between this polymorphism and the intake of dietary fats in a population with a high intake of monounsaturated fatty acids.

Key Words: Cross-sectional study • general population • dietary fatty acid • insulin resistance • FABP2 • Ala54Thr polymorphism

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