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ORIGINAL RESEARCH COMMUNICATION |
1 From the Departments of Preventive Medicine (JND, KEA, EEV, LAK, CJL, CEB-W, CMT-C, CKR, DS-M, MJW, and MIG), Pediatrics (MJW), and Physiology and Biophysics (MIG), Keck School of Medicine, University of Southern California, Los Angeles, CA
Background: Few studies have examined the relation between dietary carbohydrate quality, adiposity, and insulin dynamics in children.
Objective: The objective of the study was to determine which aspects of dietary carbohydrate, specifically dietary sugar, fiber, glycemic index, or glycemic load, are associated with adiposity and insulin dynamics in overweight Latino children.
Design: We examined 120 overweight Latino children (10–17 y old) with a family history of type 2 diabetes. Dietary intake was determined by repeated 24-h diet recalls. Adiposity was assessed by using total-body dual-energy X-ray absorptiometry. Insulin dynamics [insulin sensitivity (SI), acute insulin response, and disposition index (an index of ß-cell function)] were measured by using a frequently sampled intravenous-glucose-tolerance test.
Results: After adjustment for covariates, total sugar (g/d) was positively correlated with body mass index (BMI; in kg/m2), BMI z scores, and total fat mass (r = 0.20, r = 0.22, and r = 21, respectively; P < 0.05) and negatively correlated with SI and disposition index (r = –0.29 and r = –0.24, respectively; P < 0.05). Dietary fiber, glycemic index, and glycemic load were not significantly correlated with adiposity or insulin dynamics before or after control for covariates. Regression analyses showed that total sugar intake explained an additional 3.4%, 4.6%, and 2.4% of the variance in BMI, BMI z scores, and total fat mass, respectively, and an additional 5.6% and 4.8% of the variance in SI and disposition index (P < 0.05), respectively, after control for covariates.
Conclusion: In this cohort, total sugar intake, rather than glycemic index or glycemic load, was associated with higher adiposity measures, lower SI, and lower measures of insulin secretion.
Key Words: Insulin sensitivity • disposition index • adiposity • Latinos • children • overweight • diet • sugar • glycemic index • carbohydrate
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