HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jensen, L. Articles by Astrup, A. Search for Related Content PubMed PubMed Citation Articles by Jensen, L. Articles by Astrup, A. Agricola Articles by Jensen, L. Articles by Astrup, A.

A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women^1,2,3,4

¹ From the Department of Veterinary Pathobiology (LJ and NB) and the Department of Human Nutrition and the Center for Advanced Food Studies (BS, IK-M, AF, AR, TT, and AA), Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark

Background: The development of obesity has been suggested to involve plasminogen activator inhibitor-1 (PAI-1) and tissue inhibitor of proteinases-1 (TIMP-1). Plasma PAI-1 is elevated in obesity. A low-glycemic-index (LGI) diet may have a beneficial effect on obesity through a decrease in plasma PAI-1, but whether it affects plasma TIMP-1 in healthy humans has not been studied.

Objective: We investigated whether a 10-wk intake of an LGI or a high-glycemic-index (HGI), high-carbohydrate, low-fat, ad libitum diet is associated with decreases in plasma PAI-1 and TIMP-1 concentrations in overweight women.

Design: Forty-four overweight women [body mass index (BMI; in kg/m²): 27.5 ± 0.23] were randomly assigned to consume an HGI or an LGI diet for 10 wk. A subgroup of 29 women was assigned to participate in an additional 4-h meal test on the last day of the 10-wk intervention.

Results: PAI-1 activity decreased after 10 wk of the LGI diet and was significantly different between groups. Changes in PAI-1 antigen followed the same trend, but no significant difference was observed between groups. No difference in plasma TIMP-1 concentrations was observed between groups. PAI-1 and TIMP-1 concentrations after the 4-h meal test were not significantly different between groups.

Conclusion: An LGI diet reduces fasting plasma PAI-1 activity and therefore may be useful for diminishing the adverse cardiovascular effects of obesity. This trial was registered at clinicaltrials.gov as NCT00324090.

Key Words: Plasminogen activator inhibitor-1 • PAI-1 • tissue inhibitor of proteinases-1 • TIMP-1 • glycemic index • obesity • women

This article has been cited by other articles:

				E. M. van Schothorst, A. Bunschoten, P. Schrauwen, R. P. Mensink, and J. Keijer Effects of a high-fat, low- versus high-glycemic index diet: retardation of insulin resistance involves adipose tissue modulation FASEB J, April 1, 2009; 23(4): 1092 - 1101. [Abstract] [Full Text] [PDF]

				S. Thuy, R. Ladurner, V. Volynets, S. Wagner, S. Strahl, A. Konigsrainer, K.-P. Maier, S. C. Bischoff, and I. Bergheim Nonalcoholic Fatty Liver Disease in Humans Is Associated with Increased Plasma Endotoxin and Plasminogen Activator Inhibitor 1 Concentrations and with Fructose Intake J. Nutr., August 1, 2008; 138(8): 1452 - 1455. [Abstract] [Full Text] [PDF]