HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Perez-Martinez, P. Articles by Ordovas, J. M PubMed PubMed Citation Articles by Perez-Martinez, P. Articles by Ordovas, J. M Agricola Articles by Perez-Martinez, P. Articles by Ordovas, J. M

Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations^1,2,3

¹ From the Nutrition and Genomics Laboratory, Jean Mayer–US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA (PP-M, NY, BG-B, and JMO); the Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain (PP-M, JL-M, EG, JD-L, JR, and FP-J); the CIBER Fisiopatologia Obesidad y Nutricion (CB06/03) Instituto Salud Carlos III, Spain (PP-M, JL-M, EG, JD-L, JR, and FP-J); the Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece (NY); the Department of Epidemiology, University of Alabama, Birmingham, AL (DA); the Departments of Laboratory Medicine and Pathology (MT) and of Experimental and Clinical Pharmacology (RS), University of Minnesota, Minneapolis, MN; the Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO (MP and IB); and the Human Genetics Center, University of Texas, Houston, TX (JH)

Background: Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome.

Objective: We aimed to examine whether the presence of polymorphisms at the perilipin (PLIN) locus (PLIN1, 6209TC; PLIN4, 11482GA; PLIN5, 13041AG; and PLIN6, 14995AT) influence postprandial lipoprotein metabolism in 2 white populations.

Design: Eighty-eight healthy Spanish men and 271 healthy US subjects (men and women) underwent an oral-fat-load test in 2 independent studies. Blood samples were taken in the fasting state and during the postprandial phase at regular intervals. Total cholesterol and triacylglycerol and triacylglycerol in triacylglycerol-rich lipoproteins (TRL, large and small) were measured.

Results: Carriers of the minor C allele at the PLIN1 variant displayed lower postprandial concentrations of large-TRL triacylglycerol (Spanish subjects: P = 0.024; US subjects: P = 0.005) than did subjects carrying the T/T genotype. The same pattern was observed in the Spanish population at the PLIN4 locus (P = 0.015), and both SNPs were in strong linkage disequilibrium. In both populations, subjects carrying the minor C and A alleles at PLIN1 and PLIN4, respectively, had significantly lower postprandial concentrations of plasma triacylglycerol (P < 0.05) and lower concentrations of small-TRL triacylglycerol than did those who were homozygous for the major alleles at PLIN1 and PLIN4 (Spanish subjects: P = 0.020 and 0.008, respectively; US subjects: P = 0.021 and 0.035, respectively).

Conclusion: These 2 studies suggest that the presence of the minor C and A alleles at PLIN1 and PLIN4, respectively, are associated with a lower postprandial response that may result in lower atherogenic risk for these persons.

Key Words: Nutrigenetics • postprandial lipemia • perilipin • triacylglycerol-rich lipoproteins • single-nucleotide polymorphisms