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ORIGINAL RESEARCH COMMUNICATION |
1 From the Nutrition and Genomics Laboratory, Jean Mayer–US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA (PP-M, NY, BG-B, and JMO); the Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain (PP-M, JL-M, EG, JD-L, JR, and FP-J); the CIBER Fisiopatologia Obesidad y Nutricion (CB06/03) Instituto Salud Carlos III, Spain (PP-M, JL-M, EG, JD-L, JR, and FP-J); the Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece (NY); the Department of Epidemiology, University of Alabama, Birmingham, AL (DA); the Departments of Laboratory Medicine and Pathology (MT) and of Experimental and Clinical Pharmacology (RS), University of Minnesota, Minneapolis, MN; the Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO (MP and IB); and the Human Genetics Center, University of Texas, Houston, TX (JH)
Background: Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome.
Objective: We aimed to examine whether the presence of polymorphisms at the perilipin (PLIN) locus (PLIN1, 6209T
C; PLIN4, 11482GA; PLIN5, 13041AG; and PLIN6, 14995AT) influence postprandial lipoprotein metabolism in 2 white populations.
Design: Eighty-eight healthy Spanish men and 271 healthy US subjects (men and women) underwent an oral-fat-load test in 2 independent studies. Blood samples were taken in the fasting state and during the postprandial phase at regular intervals. Total cholesterol and triacylglycerol and triacylglycerol in triacylglycerol-rich lipoproteins (TRL, large and small) were measured.
Results: Carriers of the minor C allele at the PLIN1 variant displayed lower postprandial concentrations of large-TRL triacylglycerol (Spanish subjects: P = 0.024; US subjects: P = 0.005) than did subjects carrying the T/T genotype. The same pattern was observed in the Spanish population at the PLIN4 locus (P = 0.015), and both SNPs were in strong linkage disequilibrium. In both populations, subjects carrying the minor C and A alleles at PLIN1 and PLIN4, respectively, had significantly lower postprandial concentrations of plasma triacylglycerol (P < 0.05) and lower concentrations of small-TRL triacylglycerol than did those who were homozygous for the major alleles at PLIN1 and PLIN4 (Spanish subjects: P = 0.020 and 0.008, respectively; US subjects: P = 0.021 and 0.035, respectively).
Conclusion: These 2 studies suggest that the presence of the minor C and A alleles at PLIN1 and PLIN4, respectively, are associated with a lower postprandial response that may result in lower atherogenic risk for these persons.
Key Words: Nutrigenetics • postprandial lipemia • perilipin • triacylglycerol-rich lipoproteins • single-nucleotide polymorphisms
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  S. Deram, C. Y. Nicolau, P. Perez-Martinez, I. Guazzelli, A. Halpern, B. L. Wajchenberg, J. M. Ordovas, and S. M. Villares Effects of Perilipin (PLIN) Gene Variation on Metabolic Syndrome Risk and Weight Loss in Obese Children and Adolescents J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4933 - 4940. [Abstract] [Full Text] [PDF]
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