HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in AJCN Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bray, G. A Search for Related Content PubMed PubMed Citation Articles by Bray, G. A Agricola Articles by Bray, G. A

Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program ^1,2,3

¹ From the Pennington Biomedical Research Center, Baton Rouge, LA (GAB); the George Washington Biostatistics Center, Rockville, MD (KAJ); the Department of Medicine, University of Washington, Seatlle, WA (WYF); the Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, CA (EBC); the University of Texas Health Science Center at San Antonio, San Antonio, TX (SH); the National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ (RLH); the Center for Human Nutrition, University of Colorado School of Medicine, Denver, CO (JOH); the Division of Nutrition Research, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (VH); the Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA (AK); the University of Colorado Health Sciences Center, Denver, CO (ES); and Roosevelt-St Luke's Hospital, New York, NY (FXP-S)

Background: Greater central adiposity is related to the risk of diabetes.

Objective: We aimed to test the hypothesis that central adiposity measured by computed tomography (CT) is a better predictor of the risk of diabetes than is body mass index (BMI), waist circumference (WC), waist/hip ratio (WHR), or waist/height ratio.

Design: Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured at the L2–3 and L4–5 disc spaces in 1106 of the 3234 participants in the Diabetes Prevention Program. Sex-specific proportional hazards models were used to evaluate the association between VAT and SAT at both cuts, BMI, and other measures of central adiposity as predictors of the development of diabetes.

Results: Men had more VAT than did women. White subjects had more VAT at both cuts than did other ethnic groups. The ratio of VAT to SAT was lowest in African Americans of both sexes. Among men in the placebo group, VAT at both cuts, WC, BMI, waist/height ratio, and WHR predicted diabetes (hazard ratio: 1.79–1.44 per 1 SD of variable). Among women in the lifestyle group, VAT at both cuts predicted diabetes as well as did BMI, and L2–3 was a significantly better predictor than was WC or WHR. SAT did not predict diabetes. None of the body fat measurements predicted diabetes in the metformin group.

Conclusions: In the placebo and lifestyle groups, VAT at both cuts, WHR, and WC predicted diabetes. No measure predicted diabetes in the metformin group. CT provided no important advantage over these simple measures. SAT did not predict diabetes.

Related articles in AJCN:

Abdominal fat: does it predict the development of type 2 diabetes?

Amalia Gastaldelli
AJCN 2008 87: 1118-1119. [Full Text]  

This article has been cited by other articles:

				A. M. Martin, H. Berger, R. Nisenbaum, A. Y. Lausman, S. MacGarvie, C. Crerar, and J. G. Ray Abdominal Visceral Adiposity in the First Trimester Predicts Glucose Intolerance in Later Pregnancy Diabetes Care, July 1, 2009; 32(7): 1308 - 1310. [Abstract] [Full Text] [PDF]

				R. Izzo, G. de Simone, M. Chinali, G. Iaccarino, V. Trimarco, F. Rozza, R. Giudice, B. Trimarco, and N. De Luca Insufficient Control of Blood Pressure and Incident Diabetes Diabetes Care, May 1, 2009; 32(5): 845 - 850. [Abstract] [Full Text] [PDF]