HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kallio, P. Articles by Niskanen, L. PubMed PubMed Citation Articles by Kallio, P. Articles by Niskanen, L. Agricola Articles by Kallio, P. Articles by Niskanen, L.

Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome^1,2,3

¹ From the Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Finland (PK, MK, LP, HM, MU, and KP); the Institute of Medicine, Internal Medicine, Kuopio University Hospital, Finland (DEL and LN); the Institute of Biomedicine, Department of Physiology, University of Kuopio, Finland (DEL and MA); and VTT, Espoo, Finland (KP)

Background: Inflammation may be a mechanism by which high postprandial insulin and glucose responses increase the risk of type 2 diabetes mellitus.

Objective: We hypothesized that dietary carbohydrates characterized by different postprandial insulin responses may differentially modify cytokine concentrations in plasma and gene expression in subcutaneous adipose tissue.

Design: Individuals (n = 47) with the metabolic syndrome were randomly assigned to a 12-wk diet with oat and wheat bread and potato (high postprandial insulin response) or rye bread and pasta (low postprandial insulin response). Postprandial glucose and insulin responses to the oat and wheat bread meal and to the rye bread meal were determined in 19 individuals before intervention.

Results: During the 12-wk diet, the change in the gene expression of interleukin (IL)-10 receptor and tumor necrosis factor- in subcutaneous adipose tissue differed between the groups (P = 0.002 and P = 0.083, respectively). Moreover, the change in fasting plasma concentrations of IL-1β and IL-6 differed between the groups (P = 0.020 and P = 0.055, respectively). In the postprandial challenge, the insulin response to the rye bread meal was lower than that to the oat and wheat bread meal (P < 0.001), whereas there were no differences in the mean blood glucose response. In contrast, plasma glucose concentrations decreased more below fasting concentrations 2.5–3 h after the oat and wheat bread meal than after the rye bread meal. A late postprandial rebound of free fatty acids was detected after the oat and wheat bread meal (P = 0.048).

Conclusions: Long-term intake of cereal foods with differing postprandial insulin responses may be a factor that modulates the inflammatory status in individuals with the metabolic syndrome.

Key Words: Gene-nutrient interactions • adipose tissue • inflammation • cytokines • postprandial response