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American Journal of Clinical Nutrition, Vol. 87, No. 5, 1504-1512, May 2008
© 2008 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

Gene polymorphisms of oxidative stress enzymes: prediction of elderly renutrition1,2,3

Emmanuelle E Fabre, Agathe Raynaud-Simon, Jean-Louis Golmard, Marylise Hebert, Xavier Dulcire, Monique Succari, Jacques Myara, Dominique Durand and Valerie Nivet-Antoine

1 From the Biochemistry (EEF, MH, XD, MS, JM, DD, and VNA) and Nutrition (ARS) Departments, Charles Foix Hospital, AP-HP, Ivry sur Seine, France; the Biostatistics Department (JLG) and EA3974 (JLG), Pitie-Salpetriere Hospital, AP-HP, Paris, France; and the Paris VI (ARS and JLG), Paris XI (JM), and Paris Descartes (DD and VNA) Universities, Paris, France

Background: The free radical theory of aging suggests that damage caused by oxidative stress leads to impaired physiologic functions. This damage is stemmed by an adequate antioxidant status, which minimizes the occurrence of infection, thus potentially playing a role in improving nutritional status. The role played by genetic factors remains unknown.

Objective: The aim of this study was to investigate whether a single nucleotide polymorphism (SNP) of a gene coding for endogenous antioxidant enzymes could influence either nutritional status or renutrition process in an elderly population.

Design: Nutritional and inflammatory status were studied in 77 elderly outpatients and in 99 malnourished elderly inpatients over 6 wk of health care treatment. Renutrition efficiency was evaluated with use of the ratio between initial transthyretinemia and 6-wk variation. A genetic study was performed on superoxide dismutase (Ala-9Val), glutathione peroxidase (Pro197Leu), and catalase (from promoter to the first intron).

Results: Among the SNPs studied, the G-844A, A-89T, and C-20T catalase SNPs could each be markers predicting renutrition efficiency. These catalase mutant alleles were associated with a lower efficiency of renutrition in malnourished elderly subjects, regardless of initial nutritional and inflammatory status. Genotyping one of these catalase SNPs could make it possible to identify a high-risk subpopulation of mutant allele carriers within the elderly polypathological population.

Conclusion: In a malnutrition setting, this subpopulation should be given personalized health care, including a strengthened refeeding program. Thus, catalase genotyping could enable earlier recovery of satisfactory nutritional status and thus avoid the consequences of malnutrition, which are especially deleterious in the elderly.






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