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American Journal of Clinical Nutrition, Vol. 87, No. 6, 1837-1843, June 2008
© 2008 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration 1,2,3

Eunyoung Cho, Susan E Hankinson, Bernard Rosner, Walter C Willett and Graham A Colditz

1 From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (EC, SEH, BR, WCW); the Departments of Epidemiology (SEH, BR, WCW), Biostatistics (BR), and Nutrition (EC and WCW), Harvard School of Public Health, Boston, MA; and the Department of Surgery and Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO (GAC)

Background: The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness.

Objective: The objective was to evaluate the association between lutein/zeaxanthin intake and AMD risk by smoking status, intake of antioxidant vitamins, and body fatness.

Design: We conducted a prospective follow-up study of 71 494 women and 41 564 men aged ≥50 y and had no diagnosis of AMD or cancer. Diet was assessed with a validated semiquantitative food-frequency questionnaire.

Results: During up to 18 y of follow-up, we documented 673 incident cases of early AMD and 442 incident cases of neovascular AMD with a visual loss of 20/30 or worse due primarily to AMD. Lutein/zeaxanthin intake was not associated with the risk of self-reported early AMD. There was a statistically nonsignificant and nonlinear inverse association between lutein/zeaxanthin intake and neovascular AMD risk; the pooled multivariate relative risks for increasing quintiles of intake were 1.00 (referent), 0.80, 0.84, 0.97, and 0.72 (95% CI: 0.53, 0.99) (P for trend = 0.14). For early AMD, the association with lutein/zeaxanthin intake did not vary by smoking status, intakes of vitamins C and E, or body mass index. For neovascular AMD, a nonlinear inverse association was found among never smokers.

Conclusions: These data do not support a protective role of lutein/zeaxanthin intake on risk of self-reported early AMD. The suggestion of inverse associations related to the risk of neovascular AMD needs to be examined further.






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