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Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n–3 Fatty Acids |
1 From the Institute of Human Nutrition and the Department of Pediatrics, Columbia University Medical Center, New York, NY (RJD, SRA); the Massachusetts General Hospital and Harvard Medical School, Boston, MA (AL); the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA (DM); the Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University, Atlanta, GA (TAJ); and the Nutrition and Metabolic Diseases Research Center Sanford Research/USD and the Sanford School of Medicine of the University of South Dakota, Sioux City, SD (WSH)
ABSTRACT
After the symposium "Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n–3 Fatty Acids," faculty who presented at the conference submitted manuscripts relating to their conference topics, and these are presented in this supplement. The content of these manuscripts was reviewed, and 2 conference calls were convened. The objective was to summarize existing evidence, gaps in evidence, and future research needed to strengthen recommendations for specific intakes of n–3 fatty acids for different conditions relating to cardiovascular disease. The following 2 questions were the main items discussed. What are the roles of n–3 fatty acids in primary versus secondary prevention of coronary heart disease? What are the roles of n–3 fatty acids in hypertriglyceridemia, in the metabolic syndrome and type 2 diabetes, and in sudden cardiac death, cardiac arrhythmias, and vulnerable plaque? Each area was summarized by using 2 general categories: 1) current knowledge for which general consensus exists, and 2) recommendations for research and policy. Additional references for these conclusions can be found in the articles included in the supplement.
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