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American Journal of Clinical Nutrition, Vol. 88, No. 1, 30-37, July 2008
© 2008 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

Postprandial triglyceride responses to aerobic exercise and extended-release niacin1,2,3

Eric P Plaisance1, Michael L Mestek1, A Jack Mahurin1, J Kyle Taylor1, Jose Moncada-Jimenez1 and Peter W Grandjean1

1 From the Department of Kinesiology, Auburn University, Auburn, AL (EPP, MLM, and PWG); the Family Medicine Residency Program, Baptist Hospital, Montgomery, AL (AJM); the Department of Biology, Auburn University Montgomery, Montgomery, AL (JKT); and the School of Physical Education and Sports, University of Costa Rica, San Jose, Costa Rica (JM-J)

Background:Aerobic exercise and niacin are frequently used strategies for reducing serum triglycerides, and, yet, there is no information regarding the combined effects of these strategies on postprandial triglycerides.

Objective:We compared the effects of aerobic exercise and 6 wk of extended-release niacin on postprandial triglycerides in men with the metabolic syndrome.

Design:Fifteen participants underwent each of 4 conditions: control—high-fat meal only (100 g fat); exercise—aerobic exercise performed 1 h before a high-fat meal; niacin—high-fat meal consumed after 6 wk of niacin; and niacin + exercise—high-fat meal consumed after 6 wk of niacin and 1 h after aerobic exercise. Temporal responses for triglyceride and insulin concentrations were measured and total (AUCT) and incremental (AUCI) areas under the curve were calculated. Differences were determined by using a 2-factor repeated-measures analysis of variance (P < 0.05 for all).

Results:Exercise lowered the triglyceride AUCI by 32% compared with control (724 ± 118 and 1058 ± 137, respectively). Niacin had no influence on the triglyceride AUCI and attenuated the triglyceride-lowering effect of exercise when combined. Niacin + exercise had no effect on the triglyceride AUCI but decreased the insulin AUCI after niacin administration.

Conclusions:Aerobic exercise lowers the postprandial triglyceride response to a high-fat meal. Niacin lowers fasting but not postprandial triglycerides and appears to influence the triglyceride-lowering effect of aerobic exercise when combined. However, exercise decreases postprandial insulin concentrations after niacin administration, which illustrates the potential metabolic benefits of exercise in persons taking niacin.






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