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American Journal of Clinical Nutrition, Vol. 88, No. 3, 797-800, September 2008
© 2008 American Society for Nutrition

ORIGINAL RESEARCH COMMUNICATION

Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons1,2,3

Michaela Pichler, Barbara Kollerits, Iris M Heid, Steven C Hunt, Ted D Adams, Paul N Hopkins and Florian Kronenberg

1 From the Division of Genetic Epidemiology; Department of Medical Genetics, Molecular and Clinical Pharmacology; Innsbruck Medical University, Innsbruck, Austria (MP, BK, and FK); the Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany (IMH); the Institute of Information Management, Biometry and Epidemiology; Ludwig-Maximilians University of Munich, Munich, Germany (IMH); and the Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT (SCH, TDA, and PNH)

Background: Several studies have reported that carriers of the 103I allele of the melanocortin-4 receptor (MC4R) gene had lower body weight than did persons with the wild-type genotype. A recent study found an association of the MC4R 103I variant with carbohydrate intake, which may mediate some of the association of this variant with leanness.

Objective: The purpose of the study was to investigate the association between the MC4R V103I polymorphism and the dietary intake of persons with severe obesity, which was derived by using the Willett food-frequency questionnaire.

Design: The MC4R V103I polymorphism was genotyped in a group of 1029 severely obese white subjects with an average body mass index (BMI; in kg/m2) of 46.0 (range: 33–92).

Results: Carriers of the 103I allele had significantly higher daily energy (364 kcal/d or 19%; P = 0.03) and carbohydrate (57 g/d or 27%; P = 0.01) intakes than did noncarriers, but there was no relation with BMI. No notable association of this polymorphism with lipid and glucose variables of the metabolic syndrome was observed.

Conclusions: The higher dietary intake of carbohydrates in severely obese persons with the MC4R 103I variant is in line with previous findings. It may indicate a differential effect on body size measures in extremely obese subjects as compared with the general population.






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