AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by González, M.
Right arrow Articles by Vulpe, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by González, M.
Right arrow Articles by Vulpe, C.
Agricola
Right arrow Articles by González, M.
Right arrow Articles by Vulpe, C.
American Journal of Clinical Nutrition, Vol. 88, No. 3, 830S-834S, September 2008
© 2008 American Society for Nutrition

Systems Biology Approach to Copper Homeostasis

Expression of copper-related genes in response to copper load1,2,3,4

Mauricio González, Angélica Reyes-Jara, Miriam Suazo, William J Jo and Chris Vulpe

1 From the Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile (MG and AR-J), and the Department of Nutritional Science and Toxicology, University of California Berkeley, Berkeley, CA (WJJ and CV)

ABSTRACT

Copper is an essential micronutrient for all biological systems. Multiple proteins require one or more atoms of copper for proper structure and function, but excess of copper is toxic. To prevent the consequences of copper deficiency and overload, living organisms have evolved molecular mechanisms that regulate its uptake, intracellular traffic, storage, and efflux. Underlying some of the cellular responses to variations in copper levels are changes in the expression of genes encoding molecular components of copper metabolism. In recent years, genome-scale expression analysis in several eukaryotic models has allowed the identification of copper-responsive genes involved in copper homeostasis. Characterization of the transcriptional changes in response to varying copper levels include both genes directly involved in copper homeostasis and genes involved in different cellular process that, even though they are not directly connected to copper metabolism, change their expression during the cellular adaptation to copper availability. Evaluation of these gene expression patterns could aid in the identification of biologically relevant markers to monitor copper status in humans.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by The American Society for Nutrition