| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 MRC CAiTE Centre, Department of Social Medicine (NJT and GDS) and the Department of Community Based Medicine (PME), Bristol University, Bristol, United Kingdom; Genetics of Complex Traits (TMF and ATH) and Diabetes Genetics (TMF and ATH), Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom; the School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom (IR); the Oxford Centre for Diabetes, Endocrinology and Metabolism (MIM) and the Wellcome Trust Centre for Human Genetics (NJT and MIM), University of Oxford, Oxford, United Kingdom
Background: A region of chromosome 16 containing the fat mass–and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity.
Objectives: We aimed to assess the possibility that appetite plays a role in the association between FTO and BMI.
Design: Detailed dietary report information from the Avon Longitudinal Study of Parents and Children allowed the exploration of relations between FTO variation and dietary intake. Analyses were performed to investigate possible associations between variation at the FTO locus and the intake of a range of micronutrients and macronutrients, with adjustment for the bias often found within dietary report data when factors related to BMI are assessed. To test the hypothesis that FTO may be influencing appetite directly, rather than indirectly via BMI and altered intake requirements, we also assessed associations between FTO and dietary intake independent of BMI.
Results: Relations between a single-nucleotide polymorphism characterizing the FTO signal (rs9939609) and dietary variables were found and can be summarized by the effect of each additional allele (per-allele effects) on total energy and total fat (P < 0.001 for both). These associations were attenuated, but they persisted specifically for fat and energy consumption after adjustment for BMI [total daily fat consumption: 
1.5 g/d (P = 0.02 for the per-allele difference); total daily energy consumption: 25 kJ/d (P = 0.03 for the per-allele difference)].
Conclusion: These associations suggest that persons carrying minor variants at rs9939609 were consuming more fat and total energy than were those not carrying such variants. They also suggest that this difference was not simply dependent on having higher average BMIs among the former group.
This article has been cited by other articles:
|
|
 |
|
  M. Tanofsky-Kraff, J. C Han, K. Anandalingam, L. B Shomaker, K. M Columbo, L. E Wolkoff, M. Kozlosky, C. Elliott, L. M Ranzenhofer, C. A Roza, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating Am. J. Clinical Nutrition, December 1, 2009; 90(6): 1483 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hardy, A. K. Wills, A. Wong, C. E. Elks, N. J. Wareham, R. J.F. Loos, D. Kuh, and K. K. Ong Life course variations in the associations between FTO and MC4R gene variants and body size Hum. Mol. Genet., November 12, 2009; (2009) ddp504v2. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sonestedt, C. Roos, B. Gullberg, U. Ericson, E. Wirfalt, and M. Orho-Melander Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity Am. J. Clinical Nutrition, November 1, 2009; 90(5): 1418 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. den Hoed, M. S Westerterp-Plantenga, F. G Bouwman, E. C. Mariman, and K. R Westerterp Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO Am. J. Clinical Nutrition, November 1, 2009; 90(5): 1426 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cha, I. Koo, B. L. Park, S. Jeong, S. M. Choi, K. S. Kim, H. D. Shin, and J. Y. Kim Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types Evid. Based Complement. Altern. Med., October 11, 2009; (2009) nep162v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Staiger, F. Machicao, A. Fritsche, and H.-U. Haring Pathomechanisms of Type 2 Diabetes Genes Endocr. Rev., October 1, 2009; 30(6): 557 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Timpson, R. Harbord, G. Davey Smith, J. Zacho, A. Tybjaerg-Hansen, and B. G. Nordestgaard Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?: Mendelian Randomization Using the FTO/MC4R Genotype Hypertension, July 1, 2009; 54(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Pausova, C. Syme, M. Abrahamowicz, Y. Xiao, G. T. Leonard, M. Perron, L. Richer, S. Veillette, G. D. Smith, O. Seda, et al. A Common Variant of the FTO Gene Is Associated With Not Only Increased Adiposity but Also Elevated Blood Pressure in French Canadians Circ Cardiovasc Genet, June 1, 2009; 2(3): 260 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jonsson, P. W. Franks, C. N.A. Palmer, J. Cecil, and M. Hetherington Obesity, FTO Gene Variant, and Energy Intake in Children N. Engl. J. Med., April 9, 2009; 360(15): 1571 - 1572. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hakanen, O. T. Raitakari, T. Lehtimaki, N. Peltonen, K. Pahkala, L. Sillanmaki, H. Lagstrom, J. Viikari, O. Simell, and T. Ronnemaa FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1281 - 1287. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
