HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental data Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in AJCN Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Livesey, G. Articles by Taylor, R. Search for Related Content PubMed PubMed Citation Articles by Livesey, G. Articles by Taylor, R. Agricola Articles by Livesey, G. Articles by Taylor, R.

Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies^1,2,3

¹ From Independent Nutrition Logic, Wymondham, United Kingdom

Background: The glycemic response to dietary fructose is low, which may improve concentrations of glycated hemoglobin (HbA_1c, a marker of dysglycemia). Meanwhile, adverse effects on plasma triacylglycerol (a marker of dyslipidemia) and body weight have been questioned. Such effects are reported inconsistently.

Objective: We aimed to evaluate the effect of fructose on these health markers, particularly examining treatment dose and duration, and level of glycemic control.

Design: A literature search was conducted for relevant randomized and controlled intervention studies of crystalline or pure fructose (excluding high-fructose corn syrup), data extraction, meta-analyses, and modeling using meta-regression.

Results: Fructose intake < 90 g/d significantly improved HbA_1c concentrations dependent on the dose, the duration of study, and the continuous severity of dysglycemia throughout the range of dysglycemia. There was no significant change in body weight at intakes <100 g fructose/d. Fructose intakes of <50 g/d had no postprandially significant effect on triacylglycerol and those of 100g/d had no significant effect when subjects were fasting. At 100 g fructose/d, the effect on fasting triacylglycerol depended on whether sucrose or starch was being exchanged with fructose, and the effect was dose-dependent but was less with increasing duration of treatment. Different health types and sources of bias were examined; they showed no significant departure from a general trend.

Conclusions: The meta-analysis shows that fructose intakes from 0 to 90 g/d have a beneficial effect on HbA_1c. Significant effects on postprandial triacylglycerols are not evident unless >50 g fructose/d is consumed, and no significant effects are seen for fasting triacylglycerol or body weight with intakes of 100 g fructose/d in adults.

Related articles in AJCN:

How safe is fructose for persons with or without diabetes?

Laura Gabriela Sánchez-Lozada, MyPhuong Le, Mark Segal, and Richard J Johnson
AJCN 2008 88: 1189-1190. [Full Text]  

This article has been cited by other articles:

				G. Livesey Fructose Ingestion: Dose-Dependent Responses in Health Research J. Nutr., June 1, 2009; 139(6): 1246S - 1252S. [Abstract] [Full Text] [PDF]

				G. Livesey and H. Tagami Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): meta-analysis of randomized controlled trials Am. J. Clinical Nutrition, January 1, 2009; 89(1): 114 - 125. [Abstract] [Full Text] [PDF]

				L. G. Sanchez-Lozada, M. Le, M. Segal, and R. J Johnson How safe is fructose for persons with or without diabetes? Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1189 - 1190. [Full Text] [PDF]