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Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): meta-analysis of randomized controlled trials^1,2,3,4

¹ From Independent Nutrition Logic, Pealerswell House, Wymondham, Norfolk, United Kingdom (GL), and Matsutani Chemical Industry Co, Ltd, Itami City, Japan (HT).

² The opinions expressed herein are those of the authors and do not necessarily represent the views of the Matsutani Chemical Industry Co, Ltd.

³ The review was both commissioned from Independent Nutrition Logic Ltd and funded by the Matsutani Chemical Industry Co, Ltd, Itami City, Japan.

⁴ Address reprint requests and correspondence to G Livesey, Independent Nutrition Logic, Pealerswell House, 21 Bellrope Lane, Wymondham, Norfolk NR18 0QX, United Kingdom. E-mail: glivesey{at}inlogic.co.uk.

Background: The glycemic response to diet has been linked with noncommunicable diseases and is reduced by low-palatable, viscous, soluble fiber (1). Whether a palatable, low-viscous, soluble fiber such as resistant maltodextrin (RMD) has the same effect is unclear.

Objective: The objective was to assess evidence on the attenuation of the blood glucose response to foods by 10 g RMD in healthy adults.

Design: We conducted a systematic review of randomized, placebo-controlled trials with the use of fixed- and random-effects meta-analyses and meta-regression models.

Results: We found data from 37 relevant trials to April 2007. These trials investigated the attenuation of the glycemic response to rice, noodles, pastry, bread, and refined carbohydrates that included 30–173 g available carbohydrate. RMD was administered in drinks or liquid foods or solid foods. Placebo drinks and foods excluded RMD. Percentage attenuation was significant, dose-dependent, and independent of the amount of available carbohydrate coingested. Attenuation of the glycemic response to starchy foods by 6 g RMD in drinks approached 20%, but when placed directly into foods was 10%—significant (P < 0.001) by both modes of administration. Study quality analyses, funnel plots, and trim-and-fill analyses uncovered no cause of significant systematic bias. Studies from authors affiliated with organizations for-profit were symmetrical without heterogeneity, whereas marginal asymmetry and significant heterogeneity arose among studies involving authors from nonprofit organizations because of some imprecise studies.

Conclusions: A nonviscous palatable soluble polysaccharide can attenuate the glycemic response to carbohydrate foods. Evidence of an effect was stronger for RMD in drinks than in foods.