HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 89/3/985S    most recent ajcn.2008.26788Dv1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Williams, K. W Articles by Elmquist, J. K Search for Related Content PubMed PubMed Citation Articles by Williams, K. W Articles by Elmquist, J. K Agricola Articles by Williams, K. W Articles by Elmquist, J. K

From observation to experimentation: leptin action in the mediobasal hypothalamus

¹ From the Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX.

² Presented at the symposium "Leptin: Weight Management and Beyond," held at Experimental Biology 2008, San Diego, CA, 6 April 2008.

³ Supported by the NIH (F32 DK077487-01 to KWW; DK53301, MH61583, DK081185, and DK71320 to JKE) and by an American Diabetes Association Smith Family Foundation Pinnacle Program Award to JKE.

⁴ Reprints not available. Address correspondence to JK Elmquist, Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 85390-9051. E-mail: joel.elmquist{at}utsouthwestern.edu.

The burgeoning obesity epidemic has fueled the drive to describe, mechanistically, metabolic homeostasis. From the early theories implicating glucose as a principal modulator grew an understanding of a complex array of metabolic signals, sensed by peripheral organs along with specific locations within the central nervous system (CNS). The discovery that leptin, an adipose-derived hormone, acts within the mediobasal hypothalamus to control food intake and energy expenditure ushered in a decade of research that went on to describe not only the specific nuclei and cell type, such as proopiomelanocortin neurons of the arcuate nucleus, that respond to leptin but also the signaling cascades that mediated its effects. This review thus highlights the sites and mechanisms of action of leptin, both in the hypothalamus and in extrahypothalamic sites within the CNS, and shows our current knowledge and direction of future research aimed at understanding the multifunctional role of leptin in maintaining metabolic homeostasis.

This article has been cited by other articles:

				A. A. Pierce and A. W. Xu De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance J. Neurosci., January 13, 2010; 30(2): 723 - 730. [Abstract] [Full Text] [PDF]

				E. Lebenthal Introduction to the symposium Am. J. Clinical Nutrition, March 1, 2009; 89(3): 971S - 972S. [Full Text] [PDF]

				S. Bluher and C. S Mantzoros Leptin in humans: lessons from translational research Am. J. Clinical Nutrition, March 1, 2009; 89(3): 991S - 997S. [Abstract] [Full Text] [PDF]

				J. M Friedman Leptin at 14 y of age: an ongoing story Am. J. Clinical Nutrition, March 1, 2009; 89(3): 973S - 979S. [Abstract] [Full Text] [PDF]

				I S. Farooqi and S. O'Rahilly Leptin: a pivotal regulator of human energy homeostasis Am. J. Clinical Nutrition, March 1, 2009; 89(3): 980S - 984S. [Abstract] [Full Text] [PDF]