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American Journal of Clinical Nutrition, Vol 9, 315-319, Copyright © 1961 by The American Society for Clinical Nutrition, Inc.
1 From the Laboratory of Physiological Hygiene, University of Minnesota, Minneapolis, Minnesota
The relationship of changes in serum magnesium concentration to changes in serum cholesterol concentration was studied in controlled dietary experiments in man. Changes in serum cholesterol levels were induced by interchanging isocalorically various amounts and kinds of dietary fats and carbohydrates. In one experiment in which there was a significant increase in serum cholesterol concentration the mean serum magnesium level decreased slightly. The "within-men" correlation between magnesium and cholesterol changes was not statistically significant. In a second experiment with even greater changes in serum cholesterol levels no significant changes in serum magnesium levels were observed. It is concluded that no systematic relationship existed between changes in serum magnesium and serum cholesterol levels under the conditions of these dietary experiments.
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