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American Journal of Clinical Nutrition, Vol 9, 76-88, Copyright © 1961 by The American Society for Clinical Nutrition, Inc.

Metabolism of Alpha-Tocopherol and the Isolation of a Nontocopherol-Reducing Substance from Animal Tissues

P. ALAUPOVICacute PH.D.1, B. CONNOR JOHNSON PH.D.1, QUINCY CRIDER M.S.1, H. N. BHAGAVAN M.S.1, and B. J. JOHNSON B.S.1

1 From the Department of Animal Science, University of Illinois, Urbana, Illinois

It has been demonstrated that agr-tocopherol-5-methyl-C14 was converted in rats and pigs into three metabolites: compound F and compounds Oi and Os. These compounds are oils, and they were isolated and separated from liver extracts by a combination of column and paper chromatographic methods. Compound F, which is the main metabolite, can be reduced readily to an Emmerie-Engel-positive material. Neither compound is a quinone or hydroquinone, and neither contains phosphorus in its molecule. It has been shown that the compounds agr-tocopherylquinone, agr-tocopherylhydroquinone, agr-tocopheroxide, trimethylphytylbenzoquinone and Simon`s metabolites, which have been suggested as possible metabolic or degradation products of agr-tocopherol, are not present in rat and pig liver under conditions used in these experiments. The importance of these compounds in studying the function of vitamin E has been discussed.

The isolation of a new reducing compound from rat, chicken, and beef liver and from beef heart mitochondria has been described and its possible relationship with agr-tocopherol and other antioxidants discussed.




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W. A. Skinner and P. Alaupovic
Vitamin E Oxidation with Alkaline Ferricyanide
Science, May 17, 1963; 140(3568): 803 - 805.
[Abstract] [PDF]


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Copyright © 1961 by The American Society for Nutrition