HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 90/3/511    most recent ajcn.2008.27072v1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Manders, R. J. Articles by van Loon, L. J. PubMed PubMed Citation Articles by Manders, R. J. Articles by van Loon, L. J. Agricola Articles by Manders, R. J. Articles by van Loon, L. J.

Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage^1,2,3

¹ From the Departments of Human Movement Sciences (RJFM, BP, CPGB, TIA, and LJCvL) and Human Biology (LJCvL), Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands

² Supported by a grant from the Suikerstichting Nederland (Baarn).

³ Address correspondence to RJF Manders, Department of Human Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, Netherlands. E-mail: r.manders{at}hb.unimaas.nl.

Background: Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular comorbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes.

Objective: The objective was to assess glycemic control in type 2 diabetic subjects and healthy lean and obese control subjects under strict dietary standardization but otherwise free-living conditions, with and without the consumption of soft drinks.

Design: Obese type 2 diabetic men (n = 11) and lean (n = 10) and obese (n = 10) normoglycemic male control subjects participated in a randomized crossover study. The subjects were provided with a standardized diet in 2 periods, during which they consumed 250 mL water with or without (control) sucrose (37.5 g) 2 h after breakfast and lunch. Blood glucose concentrations were assessed by continuous glucose monitoring.

Results: In the type 2 diabetic subjects, the mean 24-h glucose concentrations were significantly elevated (9.1 ± 0.6 mmol/L), and hyperglycemia (glucose >10 mmol/L) was evident over 33 ± 8% (8 ± 2 h) of a 24-h period (P < 0.01). Hyperglycemia was rarely present in the normoglycemic lean and obese control subjects (5 ± 2%/24 h for both). Consumption of 75 g sucrose, equivalent to 2 cans of a soft drink, did not further augment the prevalence of hyperglycemia throughout the day in any group.

Conclusions: Type 2 diabetic subjects taking oral blood glucose–lowering medication experience hyperglycemia during most of the daytime. Moderate consumption of sucrose-sweetened beverages does not further increase the prevalence of hyperglycemia in type 2 diabetic subjects or in normoglycemic lean or obese men.