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Dietary fat intake and subsequent weight change in adults: results from the European Prospective Investigation into Cancer and Nutrition cohorts^1,2,3

¹ From the MRC Epidemiology Unit Institute of Metabolic Science Cambridge United Kingdom (NGF SJSNJW); the National Institute for Public Healththe Environment Bilthoven Netherlands (HDDLvdA); the Department of Human Biology NutritionToxicology Research Institute of Maastricht Maastricht Netherlands (HD); the Danish Cancer Society Institute of Cancer Epidemiology Copenhagen Denmark (JHAT); the Public Health Nutrition Unit Technische Universität München Freising Germany (MBS); the Department of Clinical Epidemiology Aarhus University Hospital Aalborg Denmark (KOUJ); the Department of Cardiology Aalborg Hospital Aarhus University Hospital Aalborg Denmark (KO); the Department of Epidemiology German Institute of Human Nutrition Potsdam Germany (HBBB); the MolecularNutritional Epidemiology Unit Cancer ResearchPrevention Institute–ISPO Florence Italy (DPGM); the Division of Human Nutrition Wageningen University Wageningen Netherlands (EJMF);the Institute of Preventive Medicine Copenhagen University Hospital Centre for HealthSociety Copenhagen Denmark (TIAS).

² The views expressed herein are those of the authorsshould not be construed to represent the positions of any of the sponsors of the study.

³ Address correspondence to NG Forouhi, MRC Epidemiology Unit, Institute of Medical Science, PO Box 285, Addenbrooke's Hospital Hills Road, Cambridge CB2 0QQ, United Kingdom. E-mail: nita.forouhi{at}mrc-epid.cam.ac.uk.

Background: It is unclear from the inconsistent epidemiologic evidence whether dietary fat intake is associated with future weight change.

Objective: The objective was to assess the association between the amount and type of dietary fat and subsequent weight change (follow-up weight minus baseline weight divided by duration of follow-up).

Design: We analyzed data from 89,432 men and women from 6 cohorts of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Using country-specific food-frequency questionnaires, we examined the association between baseline fat intake (amount and type of total, saturated, polyunsaturated, and monounsaturated fats) and annual weight change by using the residual, nutrient density, and energy-partition methods. We used random-effects meta-analyses to obtain pooled estimates across centers.

Results: Mean total fat intake as a percentage of energy intake ranged between 31.5% and 36.5% across the 6 cohorts (58% women; mean ± SD age: 53.2 ± 8.6 y). The mean (±SD) annual weight change was 109 ± 817 g/y in men and 119 ± 823 g/y in women. In pooled analyses adjusted for anthropometric, dietary, and lifestyle factors and follow-up period, no significant association was observed between fat intake (amount or type) and weight change. The difference in mean annual weight change was 0.90 g/y (95% CI: –0.54, 2.34 g/y) for men and –1.30 g/y (95% CI: –3.70, 1.11 g/y) for women per 1 g/d energy-adjusted fat intake (residual method).

Conclusions: We found no significant association between the amount or type of dietary fat and subsequent weight change in this large prospective study. These findings do not support the use of low-fat diets to prevent weight gain.