HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Publish Ahead of Print[PDF]) All Versions of this Article: 90/3/822S    most recent ajcn.2009.27462Tv1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kokrashvili, Z. Articles by Margolskee, R. F Search for Related Content PubMed PubMed Citation Articles by Kokrashvili, Z. Articles by Margolskee, R. F Agricola Articles by Kokrashvili, Z. Articles by Margolskee, R. F

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones^1,2,3,4

¹ From the Department of Neuroscience, Mount Sinai School of Medicine, New York, NY.

² Presented at the "100th Anniversary Symposium of Umami Discovery: The Roles of Glutamate in Taste, Gastrointestinal Function, Metabolism, and Physiology," held in Tokyo, Japan, 10–13 September 2008.

³ Supported in part by NIH grant DC03055 to RFM.

⁴ Address correspondence to RF Margolskee, Department of Neuroscience, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1065, New York, NY 10029. E-mail: robert.margolskee{at}mssm.edu.

ABSTRACT

Many of the receptors and downstream signaling elements involved in taste detection and transduction are also expressed in enteroendocrine cells where they underlie the chemosensory functions of the gut. In one well-known example of gastrointestinal chemosensation (the "incretin effect"), it is known that glucose that is given orally, but not systemically, induces secretion of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide (the incretin hormones), which in turn regulate appetite, insulin secretion, and gut motility. Duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Knockout mice that lack gustducin or the sweet taste receptor subunit T1r3 have deficiencies in secretion of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide and in the regulation of plasma concentrations of insulin and glucose in response to orally ingested carbohydrate—ie, their incretin effect is dysfunctional. Isolated small intestine and intestinal villi from gustducin null mice displayed markedly defective glucagon-like peptide 1 secretion in response to glucose, indicating that this is a local circuit of sugar detection by intestinal cells followed by hormone secretion from these same cells. Modulating hormone secretion from gut "taste cells" may provide novel treatments for obesity, diabetes, and malabsorption syndromes.

This article has been cited by other articles:

				J. D Fernstrom Introduction to the symposium Am. J. Clinical Nutrition, September 1, 2009; 90(3): 705S - 706S. [Full Text] [PDF]

				R. A Hawkins The blood-brain barrier and glutamate Am. J. Clinical Nutrition, September 1, 2009; 90(3): 867S - 874S. [Abstract] [Full Text] [PDF]

				R. I Curtis Umami and the foods of classical antiquity Am. J. Clinical Nutrition, September 1, 2009; 90(3): 712S - 718S. [Abstract] [Full Text] [PDF]

				P. J Magistretti Role of glutamate in neuron-glia metabolic coupling Am. J. Clinical Nutrition, September 1, 2009; 90(3): 875S - 880S. [Abstract] [Full Text] [PDF]

				J. D Fernstrom Symposium summary Am. J. Clinical Nutrition, September 1, 2009; 90(3): 881S - 885S. [Full Text] [PDF]

				G. K Beauchamp Sensory and receptor responses to umami: an overview of pioneering work Am. J. Clinical Nutrition, September 1, 2009; 90(3): 723S - 727S. [Abstract] [Full Text] [PDF]

				N. Chaudhari, E. Pereira, and S. D Roper Taste receptors for umami: the case for multiple receptors Am. J. Clinical Nutrition, September 1, 2009; 90(3): 738S - 742S. [Abstract] [Full Text] [PDF]

				A. San Gabriel, T. Maekawa, H. Uneyama, and K. Torii Metabotropic glutamate receptor type 1 in taste tissue Am. J. Clinical Nutrition, September 1, 2009; 90(3): 743S - 746S. [Abstract] [Full Text] [PDF]

				K. Yasumatsu, N. Horio, Y. Murata, S. Shirosaki, T. Ohkuri, R. Yoshida, and Y. Ninomiya Multiple receptors underlie glutamate taste responses in mice Am. J. Clinical Nutrition, September 1, 2009; 90(3): 747S - 752S. [Abstract] [Full Text] [PDF]

				S. C Kinnamon Umami taste transduction mechanisms Am. J. Clinical Nutrition, September 1, 2009; 90(3): 753S - 755S. [Abstract] [Full Text] [PDF]

				A. A Bachmanov, M. Inoue, H. Ji, Y. Murata, M. G Tordoff, and G. K Beauchamp Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses Am. J. Clinical Nutrition, September 1, 2009; 90(3): 756S - 763S. [Abstract] [Full Text] [PDF]

				M. Raliou, A. Wiencis, A.-M. Pillias, A. Planchais, C. Eloit, Y. Boucher, D. Trotier, J.-P. Montmayeur, and A. Faurion Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate Am. J. Clinical Nutrition, September 1, 2009; 90(3): 789S - 799S. [Abstract] [Full Text] [PDF]

				L. F Donaldson, L. Bennett, S. Baic, and J. K Melichar Taste and weight: is there a link? Am. J. Clinical Nutrition, September 1, 2009; 90(3): 800S - 803S. [Abstract] [Full Text] [PDF]

				E. T Rolls Functional neuroimaging of umami taste: what makes umami pleasant? Am. J. Clinical Nutrition, September 1, 2009; 90(3): 804S - 813S. [Abstract] [Full Text] [PDF]

				F. Blachier, C. Boutry, C. Bos, and D. Tome Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines Am. J. Clinical Nutrition, September 1, 2009; 90(3): 814S - 821S. [Abstract] [Full Text] [PDF]

				Y. Akiba and J. D Kaunitz Luminal chemosensing and upper gastrointestinal mucosal defenses Am. J. Clinical Nutrition, September 1, 2009; 90(3): 826S - 831S. [Abstract] [Full Text] [PDF]

				S. Yamamoto, M. Tomoe, K. Toyama, M. Kawai, and H. Uneyama Can dietary supplementation of monosodium glutamate improve the health of the elderly? Am. J. Clinical Nutrition, September 1, 2009; 90(3): 844S - 849S. [Abstract] [Full Text] [PDF]

				Q.-Y. Chen, S. Alarcon, A. Tharp, O. M Ahmed, N. L Estrella, T. A Greene, J. Rucker, and P. A. Breslin Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes Am. J. Clinical Nutrition, September 1, 2009; 90(3): 770S - 779S. [Abstract] [Full Text] [PDF]

				T. Kondoh, H. N. Mallick, and K. Torii Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeostasis Am. J. Clinical Nutrition, September 1, 2009; 90(3): 832S - 837S. [Abstract] [Full Text] [PDF]

				D. G Burrin and B. Stoll Metabolic fate and function of dietary glutamate in the gut Am. J. Clinical Nutrition, September 1, 2009; 90(3): 850S - 856S. [Abstract] [Full Text] [PDF]

				J. A Mennella, C. A Forestell, L. K Morgan, and G. K Beauchamp Early milk feeding influences taste acceptance and liking during infancy Am. J. Clinical Nutrition, September 1, 2009; 90(3): 780S - 788S. [Abstract] [Full Text] [PDF]

				C. A Stanley Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children Am. J. Clinical Nutrition, September 1, 2009; 90(3): 862S - 866S. [Abstract] [Full Text] [PDF]

				N. Shigemura, S. Shirosaki, T. Ohkuri, K. Sanematsu, A. S. Islam, Y. Ogiwara, M. Kawai, R. Yoshida, and Y. Ninomiya Variation in umami perception and in candidate genes for the umami receptor in mice and humans Am. J. Clinical Nutrition, September 1, 2009; 90(3): 764S - 769S. [Abstract] [Full Text] [PDF]

				M. E Brosnan and J. T Brosnan Hepatic glutamate metabolism: a tale of 2 hepatocytes Am. J. Clinical Nutrition, September 1, 2009; 90(3): 857S - 861S. [Abstract] [Full Text] [PDF]

				K. Kurihara Glutamate: from discovery as a food flavor to role as a basic taste (umami) Am. J. Clinical Nutrition, September 1, 2009; 90(3): 719S - 722S. [Abstract] [Full Text] [PDF]

				C. Sano History of glutamate production Am. J. Clinical Nutrition, September 1, 2009; 90(3): 728S - 732S. [Abstract] [Full Text] [PDF]

				D. Tome, J. Schwarz, N. Darcel, and G. Fromentin Protein, amino acids, vagus nerve signaling, and the brain Am. J. Clinical Nutrition, September 1, 2009; 90(3): 838S - 843S. [Abstract] [Full Text] [PDF]

				J. R Krebs The gourmet ape: evolution and human food preferences Am. J. Clinical Nutrition, September 1, 2009; 90(3): 707S - 711S. [Abstract] [Full Text] [PDF]

				X. Li T1R receptors mediate mammalian sweet and umami taste Am. J. Clinical Nutrition, September 1, 2009; 90(3): 733S - 737S. [Abstract] [Full Text] [PDF]