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Original Research Communications |
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ABSTRACT |
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 TOP ABSTRACT INTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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Objective: We examined the health benefits of leanness and the hazards of obesity while simultaneously considering cardiorespiratory fitness.
Design: This was an observational cohort study. We followed 21925 men, aged 30–83 y, who had a body-composition assessment and a maximal treadmill exercise test. There were 428 deaths (144 from CVD, 143 from cancer, and 141 from other causes) in an average of 8 y of follow-up (176742 man-years).
Results: After adjustment for age, examination year, cigarette smoking, alcohol intake, and parental history of ischemic heart disease, unfit (low cardiorespiratory fitness as determined by maximal exercise testing), lean men had double the risk of all-cause mortality of fit, lean men (relative risk: 2.07; 95% CI: 1.16, 3.69; P = 0.01). Unfit, lean men also had a higher risk of all-cause and CVD mortality than did men who were fit and obese. We observed similar results for fat and fat-free mass in relation to mortality. Unfit men had a higher risk of all-cause and CVD mortality than did fit men in all fat and fat-free mass categories. Similarly, unfit men with low waist girths (<87 cm) had greater risk of all-cause mortality than did fit men with high waist girths (
99 cm).
Conclusions: The health benefits of leanness are limited to fit men, and being fit may reduce the hazards of obesity.
Key Words: Body composition • cardiorespiratory fitness • epidemiology • mortality • cardiovascular disease mortality • all-cause mortality • fat mass • fat-free mass • waist girth • men
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INTRODUCTION |
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TOPABSTRACTINTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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Another unexplored methodologic limitation in obesity research is that body mass index (BMI; in kg/m2) is commonly used to examine the obesity-mortality association even though BMI is not an accurate measure of obesity. Rather, it mainly indicates overweight for height but does not discriminate between fat mass and fat-free mass (FFM). Some studies show higher death rates in individuals with low BMIs and high waist-to-hip circumference ratios (WHRs), but not in those with high BMIs and low WHRs (11–13). The health effects of overweight on height and body composition in relation to cardiovascular disease (CVD) risk factors need further research (14, 15). There has been little research on the relation between measured body fatness and mortality (16).
We believe that cardiorespiratory fitness should also be considered in examining the relation between body composition and mortality. Cardiorespiratory fitness is a powerful predictor of all-cause and CVD mortality (17–19) and appeared to attenuate the relation between BMI and mortality in an earlier study (20). However, the health effects of body fatness and cardiorespiratory fitness in relation to longevity remain unexplored. Therefore, the purpose of this study was to examine the health consequences of body fatness and cardiorespiratory fitness in relation to all-cause and CVD mortality in men. We also assessed the associations of fat mass, FFM, and waist circumference to mortality after taking cardiorespiratory fitness into account.
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SUBJECTS AND METHODS |
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TOPABSTRACTINTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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85% of their age-predicted maximal heart rate [220 - age (in y)] during their treadmill tests.
The study protocol was reviewed and approved annually by the Institutional Review Board. All subjects gave their informed, written consent for the medical evaluation and subsequent registration in the follow-up study. The medical evaluation, performed after subjects had fasted overnight for 12 h, included a physical examination, anthropometric measurements, electrocardiogram, blood chemistry analyses, blood pressure assessment, maximal exercise treadmill test, self-report of health habits, and recording of demographic characteristics. Additional details of examination procedures are published elsewhere (17–19).
Serum samples were analyzed by automated techniques in a laboratory that participates in the Centers for Disease Control and Prevention Lipid Standardization Program, and blood pressure was measured by auscultatory methods with a mercury sphygmomanometer. Body weight and stature were measured with a standard physician's scale and stadiometer. In a subgroup of 14043 men, waist circumference was measured at the level of the umbilicus with a plastic tape measure. Body composition was assessed either by hydrostatic weighing, by skinfold-thickness measurements, or both following a standard procedure (21). We determined percentage body fat in men by hydrodensitometry using Siri's (22) two-component model. We also measured the sum of 7 (
7) skinfold thicknesses and estimated skinfold fat using a generalized body density equation (23).
Not all subjects underwent both hydrostatic weighing and skinfold-thickness measurements; 9655 were measured for skinfold thickness only, 7180 for hydrostatic weight only, and 5090 for both measurements. To standardize these measurements, we developed a prediction model for hydrostatistically determining percentage body fat from percentage fat (%fat) estimated by 7 skinfold thicknesses from the 5090 men who provided both 7 skinfold thicknesses and hydrostatic weighing data. A regression analysis provided the following equation:
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| (1) |
(SEE = 3.78; r = 0.82). We applied this prediction model to the skinfold data for the men who did not undergo hydrostatic weighing to estimate their percentage body fat. We further calculated fat mass and FFM (in kg) as follows:
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| (2) |
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| (3) |
We assigned subjects to categories of lean, normal, or obese. These categories correspond to <25th, 25th to <75th, and 75th percentile scores. We also classified subjects as having low, moderate, and high categories of fat mass, FFM, and waist circumference by using these same percentile scores cutoff points.
Alcohol use, cigarette smoking habit, and parental history of ischemic heart disease (IHD; either parent died of IHD) were assessed by self-report on a medical history questionnaire. Alcohol consumption was classified as none, light (<15 units/wk), moderate (15–30 units/wk), and heavy (31 units/wk). One unit of alcohol intake was defined as a bottle or can of beer [355 mL (12 oz)], a glass of wine [148 mL (5 oz)], or 44 mL (1.5 oz) of hard liquor. Smoking status was classified as never smoked, former smoker, or current smoker. Current smokers were further classified as smoking <20, 20 to <40, and 40 cigarettes/d.
Cardiorespiratory fitness was measured by using a maximal treadmill exercise test as described previously (17). Total treadmill endurance time was used as an index of aerobic power; time on treadmill with this protocol correlated highly (r = 0.92) with maximal oxygen uptake (
O2max) (24). Men in the least-fit 20% of each age group were classified as physically unfit, and all others as physically fit (18). We also calculated O2max in mL
kg FFM-1min-1 and classified men in the lowest quartile of oxygen uptake in each age group as physically unfit, and all others as physically fit. All subjects were cross-tabulated by cardiorespiratory fitness levels across body fatness categories as follows: 1) fit and lean, 2) unfit and lean, 3) fit and normal, 4) unfit and normal, (5) fit and obese, and 6) unfit and obese. We also cross-tabulated by cardiorespiratory fitness levels across fat mass, FFM, and waist circumference categories.
All subjects were followed for mortality from the baseline examination to the date of death or to December 31, 1989. Deaths among study subjects were identified from the National Center for Health Statistics National Death Index and official death certificates from the departments of vital records of the various states. The underlying cause of death was determined by a nosologist according to the International Classification of Diseases, Ninth Edition, with CVD defined as codes 390 to 449.9.
Statistical analysis
All-cause and CVD death rates per 10000 man-years (for which a man-year is 1 man followed for 1 y) of follow-up, adjusted for age and examination year, were calculated across body fatness and waist circumference categories. Proportional hazards regression was used to examine the associations among cardiorespiratory fitness, body fatness, and all-cause and CVD mortality (25). We also examined the associations among cardiorespiratory fitness, fat mass, FFM, and waist circumference to all-cause and CVD mortality. The relative risks (RRs) of all-cause and CVD mortality were estimated after adjustment for age and examination year and further adjustment for cigarette smoking, alcohol intake, and parental history of IHD. Physically fit men in the lowest quartile of each body composition variable were the reference category. The 95% CIs were calculated for each RR. All statistical procedures were performed with SAS software (26).
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RESULTS |
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TOPABSTRACTINTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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. Unfit men had a slightly higher degree of body fatness than did their fit counterparts within lean, normal, and obese categories [0.6%, 0.8%, and 1.8% higher, respectively (P < 0.001)]; treadmill times were progressively lower in unfit men, indicating lower cardiorespiratory fitness, across lean, normal, and obese categories. Fit, lean men had the highest average estimated maximal aerobic power [13.4 metabolic equivalents (METs); 1 MET = O2 (3.5 mLkg-1min-1)], whereas unfit, obese men had the lowest average maximal aerobic power (8.7 METs). We tested differences between groups with a two-factor analysis of variance (continuous data) or log linear models (categorical data). The main effects for both fitness and fatness were highly significant (P < 0.001) for all variables except that height was not related to fatness. We also tested fitness and fatness interactions, and all were significant (P 
0.001) except height, diastolic blood pressure, and serum glucose.
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. There was a direct relation between body fatness and all-cause (P = 0.01 for linear trend) and CVD (P = 0.004 for linear trend) death rates.
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. Cox proportional hazards regression analyses, adjusted for age and examination year, showed that fit men had lower death rates than did their unfit counterparts within lean, normal, and obese categories. Unfit, lean men had twice the risk of all-cause mortality as did fit, lean men (P = 0.02) and also had higher risk (2.2 times) of all-cause mortality when compared with fit, obese men (P = 0.008). The all-cause mortality rate of fit, obese men was not significantly different from that of fit, lean men. These results were similar after additional adjustment for cigarette smoking, alcohol intake, and parental history of IHD. To evaluate further the possible bias of subclinical disease at baseline, we constructed another multivariate model by adding baseline electrocardiographic status (normal or abnormal). This analysis led to adjusted RRs that were nearly identical to those reported in Table 2. Exclusion for early mortality also made little difference in these results (Figure 2).
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). Of nonsmokers, unfit, lean men had 1.7 times the risk of all-cause mortality of fit, lean men, with the highest all-cause mortality in unfit, obese men (RR: 1.97; 95% CI: 1.35, 2.88). Unfit nonsmokers in all body-composition groups had higher mortality risks than did fit nonsmokers after further exclusion for early mortality.
Unfit, lean men also had a high risk of CVD mortality when compared with their fit counterparts in all body fatness categories (Table 2). After multivariate adjustment for age, examination year, cigarette smoking, alcohol intake, and parental history of IHD, we observed that fit, lean men had the lowest CVD mortality, and that unfit, obese men had the highest. Unfit, lean men had 3.2 times the risk of CVD mortality of fit, lean men (95% CI: 1.12, 8.92; P = 0.03). However, fit, obese men had a lower risk of CVD mortality than did unfit, lean men.
When we further examined the relation of estimatedO2max (in mLkg FFM-1min-1) and body fatness with all-cause and CVD mortality (Figure 3), similar results were obtained as for analyses in which fitness was expressed in mLkg-1min-1. Mortality risk was elevated in unfit, lean men, with the highest all-cause and CVD mortality in unfit, obese men. Unfit men had substantially higher risk of CVD in all fatness categories, but there also was a direct association between body fatness and CVD mortality in fit men (P = 0.05 for linear trend).
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). Unfit men had a higher risk of all-cause and CVD mortality than did fit men in all fat mass and FFM categories. Unfit men in the lowest quartile of fat mass and FFM had a greater risk of all-cause and CVD mortality than did fit men in the highest quartile of fat mass and FFM.
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. After multivariate adjustment for age, examination year, cigarette smoking, alcohol intake, and parental history of IHD, we observed that fit men had lower risk of all-cause mortality in all waist circumference categories than unfit men. Unfit men in the lowest quartile of waist girth had 4.9 times (P < 0.001) the risk of all-cause mortality of their peers who were fit. In contrast, fit men in the highest quartile of waist girth had no elevated risk of all-cause mortality and had much lower mortality risk than unfit men in the lowest quartile of waist girth.
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DISCUSSION |
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TOPABSTRACTINTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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We observed similar results across strata of fat mass and FFM. Unfit men in the lowest quartile of fat mass and FFM had a greater risk of all-cause and CVD mortality than their fit counterparts. Fit men in the highest quartile of fat mass and FFM had a lower risk of all-cause and CVD mortality than did unfit, lean men. Our data indicate that cardiorespiratory fitness levels in men influence the health effects of obesity. We did not observe elevated mortality risk in men with high amounts of fat mass and FFM if they also were fit.
Several studies report that abdominal obesity is associated with elevated death rates (11–13). Although WHR has been commonly used to examine abdominal obesity, some studies suggest that waist girth rather than WHR is a better predictor of abdominal obesity (28–30). Measurement of waist girth instead of WHR for risk stratification is recommended in recent guidelines from the US National Institutes of Health and the World Health Organization (31, 32). Björntorp (33) reports that abdominal obesity, rather than peripheral obesity, also is associated with increased risk. Some studies show higher death rates in those with abdominal obesity who were underweight (a low BMI and high WHR) than in those without abdominal obesity who were overweight (a high BMI and low WHR) (11–13). No prior studies have reported the health effects of waist girth while also considering cardiorespiratory fitness. Our data show that fit men with low waist girth had lower risk of all-cause mortality than did unfit men in the same waist girth category. Unfit men with a high waist girth had a death rate 2.4 times greater than did the fit men with low waist girth, and fit men in the high waist girth category had a rate of all-cause mortality similar to fit men with low waist girth.
Our results support the hypothesis that moderate-to-high cardiorespiratory fitness reduces mortality risk across categories of body composition. Although most researchers agree that obesity is associated with health hazards and leanness is associated with health benefits, lean men in our study had increased longevity only if they were physically fit; furthermore, obese men who were fit did not have elevated mortality. In general, unfit, lean men were inactive and had low aerobic power despite their favorable IHD risk factor profiles at baseline, whereas fit, obese men were highly active and had high aerobic power at baseline.
A limitation of our study was that our subjects were white men in the middle and upper socioeconomic levels, although this homogeneity reduces the likelihood of confounding by socioeconomic characteristics. We hope that other investigators will examine these issues in other populations. The possibility of bias due to baseline health status is a consideration in all observational studies, including this one, but we think that serious bias is unlikely in this case because all study participants were given extensive medical examinations at baseline, which enabled us to exclude those with a history of myocardial infarction, stroke, or cancer. In addition, men who failed to achieve 85% of their age-predicted maximal heart rate on the maximal exercise test were excluded; this should have eliminated men who did not have a history of disease but were not feeling well as a result of an undiagnosed condition. We also adjusted the analyses for presence or absence of an abnormal electrocardiogram result. This exclusion eliminated men with angina, arrhythmia, or electrocardiographic abnormalities on the treadmill test, as well as resting electrocardiographic abnormalities. The effect of all these exclusion criteria was to minimize the possible bias of baseline subclinical disease. Another limitation of our study was that we estimated, rather than directly measured, residual lung volume during underwater weighing. Morrow et al (34) reported that the prediction accuracy of body fatness measured by densitometry when residual lung volume was estimated was only slightly better than anthropometric assessments. Nonetheless, the densitometry and skinfold-thickness estimates of body composition were likely to be more accurate measures of body fatness than BMI or height-weight indexes. Finally, we had only a one-time assessment of the exposure variables of cardiorespiratory fitness and body composition, and we do not know the extent to which these characteristics might have changed during follow-up. However, changes in the exposure variables during follow-up would cause misclassification and would be likely to lead to underestimates of RRs. Therefore, the true associations between fitness or body fatness and mortality may have actually been stronger than indicated by our results.
In summary, we found that obesity did not appear to increase mortality risk in fit men. For long-term health benefits we should focus on improving fitness by increasing physical activity rather than relying only on diet for weight control. Aerobic exercise improves IHD risk factors (35), and increases in physical activity or fitness extend longevity (18, 36). Although some studies show that there is no difference between diet and aerobic exercise in reducing IHD risk factors (37–39), or even report that diet is better than aerobic exercise for improving IHD risk factors in overweight men (40), our data show that fit men had greater longevity than unfit men regardless of their body composition or risk factor status. Obese men should be encouraged to increase their cardiorespiratory fitness by engaging in regular, moderate-intensity physical activity; this should benefit them even if they remain overweight.
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ACKNOWLEDGMENTS |
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FOOTNOTES |
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2 Supported in part by US Public Health Service research grant AG06945 from the National Institute on Aging, Bethesda, MD, and Polar Electro Oy, Kempele, Finland.
3 Address reprint requests to SN Blair, 12330 Preston Road, Dallas, TX 75230. E-mail: sblair{at}cooperinst.org.
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REFERENCES |
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TOPABSTRACTINTRODUCTIONSUBJECTS AND METHODSRESULTSDISCUSSIONREFERENCES |
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 S.D.H. Malnick and H. Knobler The medical complications of obesity QJM, September 1, 2006; 99(9): 565 - 579. [Full Text] [PDF]
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S. E. Ramsay, P. H. Whincup, A. G. Shaper, and S. G. Wannamethee The Relations of Body Composition and Adiposity Measures to Ill Health and Physical Disability in Elderly Men Am. J. Epidemiol., September 1, 2006; 164(5): 459 - 469. [Abstract] [Full Text] [PDF]
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J. R Ruiz, N. S Rizzo, A. Hurtig-Wennlof, F. B Ortega, J. Warnberg, and M. Sjostrom Relations of total physical activity and intensity to fitness and fatness in children: the European Youth Heart Study. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 299 - 303. [Abstract] [Full Text] [PDF]
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F. Bacha, R. Saad, N. Gungor, and S. A. Arslanian Are Obesity-Related Metabolic Risk Factors Modulated by the Degree of Insulin Resistance in Adolescents? Diabetes Care, July 1, 2006; 29(7): 1599 - 1604. [Abstract] [Full Text] [PDF]
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 F. W. Booth and M. V. Chakravarthy Physical activity and dietary intervention for chronic diseases: a quick fix after all? J Appl Physiol, May 1, 2006; 100(5): 1439 - 1440. [Full Text] [PDF]
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 P. Poirier, T. D. Giles, G. A. Bray, Y. Hong, J. S. Stern, F. X. Pi-Sunyer, and R. H. Eckel Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol, May 1, 2006; 26(5): 968 - 976. [Abstract] [Full Text] [PDF]
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P. Poirier, T. D. Giles, G. A. Bray, Y. Hong, J. S. Stern, F. X. Pi-Sunyer, and R. H. Eckel Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation, February 14, 2006; 113(6): 898 - 918. [Abstract] [Full Text] [PDF]
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L. H. Kuller Prevention of Coronary Heart Disease and the National Cholesterol Education Program Circulation, February 7, 2006; 113(5): 598 - 600. [Full Text] [PDF]
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L. Breslow Commentary: On 'public health aspects of weight control' Int. J. Epidemiol., February 1, 2006; 35(1): 12 - 14. [Full Text] [PDF]
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P. Campos, A. Saguy, P. Ernsberger, E. Oliver, and G. Gaesser The epidemiology of overweight and obesity: public health crisis or moral panic? Int. J. Epidemiol., February 1, 2006; 35(1): 55 - 60. [Full Text] [PDF]
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S. N Blair and M. J LaMonte Commentary: Current perspectives on obesity and health: black and white, or shades of grey? Int. J. Epidemiol., February 1, 2006; 35(1): 69 - 72. [Full Text] [PDF]
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T. Y. Li, J. S. Rana, J. E. Manson, W. C. Willett, M. J. Stampfer, G. A. Colditz, K. M. Rexrode, and F. B. Hu Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women Circulation, January 31, 2006; 113(4): 499 - 506. [Abstract] [Full Text] [PDF]
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S. N. Blair and M. J. LaMonte How Much and What Type of Physical Activity Is Enough?: What Physicians Should Tell Their Patients Arch Intern Med, November 14, 2005; 165(20): 2324 - 2325. [Full Text] [PDF]
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T. S. Church, M. J. LaMonte, C. E. Barlow, and S. N. Blair Cardiorespiratory Fitness and Body Mass Index as Predictors of Cardiovascular Disease Mortality Among Men With Diabetes Arch Intern Med, October 10, 2005; 165(18): 2114 - 2120. [Abstract] [Full Text] [PDF]
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A. L. Carrel, R. R. Clark, S. E. Peterson, B. A. Nemeth, J. Sullivan, and D. B. Allen Improvement of Fitness, Body Composition, and Insulin Sensitivity in Overweight Children in a School-Based Exercise Program: A Randomized, Controlled Study Arch Pediatr Adolesc Med, October 1, 2005; 159(10): 963 - 968. [Abstract] [Full Text] [PDF]
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S. Lee, J. L. Kuk, L. E. Davidson, R. Hudson, K. Kilpatrick, T. E. Graham, and R. Ross Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without Type 2 diabetes J Appl Physiol, September 1, 2005; 99(3): 1220 - 1225. [Abstract] [Full Text] [PDF]
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J.-P. Despres Our Passive Lifestyle, Our Toxic Diet, and the Atherogenic/Diabetogenic Metabolic Syndrome: Can We Afford to Be Sedentary and Unfit? Circulation, July 26, 2005; 112(4): 453 - 455. [Full Text] [PDF]
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J. M Jakicic and A. D Otto Physical activity considerations for the treatment and prevention of obesity Am. J. Clinical Nutrition, July 1, 2005; 82(1): 226S - 229S. [Abstract] [Full Text] [PDF]
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A. Lucia, F. Gomez-Gallego, I. Barroso, M. Rabadan, F. Bandres, A. F. San Juan, J. L. Chicharro, U. Ekelund, S. Brage, C. P. Earnest, et al. PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men J Appl Physiol, July 1, 2005; 99(1): 344 - 348. [Abstract] [Full Text] [PDF]
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D. D. Christou, C. L. Gentile, C. A. DeSouza, D. R. Seals, and P. E. Gates Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men Circulation, April 19, 2005; 111(15): 1904 - 1914. [Abstract] [Full Text] [PDF]
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B. Gutin, Z. Yin, M. C Humphries, and P. Barbeau Relations of moderate and vigorous physical activity to fitness and fatness in adolescents Am. J. Clinical Nutrition, April 1, 2005; 81(4): 746 - 750. [Abstract] [Full Text] [PDF]
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S. Lee, J. L. Kuk, P. T. Katzmarzyk, S. N. Blair, T. S. Church, and R. Ross Cardiorespiratory Fitness Attenuates Metabolic Risk Independent of Abdominal Subcutaneous and Visceral Fat in Men Diabetes Care, April 1, 2005; 28(4): 895 - 901. [Abstract] [Full Text] [PDF]
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P. T. Katzmarzyk, T. S. Church, I. Janssen, R. Ross, and S. N. Blair Metabolic Syndrome, Obesity, and Mortality: Impact of cardiorespiratory fitness Diabetes Care, February 1, 2005; 28(2): 391 - 397. [Abstract] [Full Text] [PDF]
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 F. B. Hu, W. C. Willett, T. Li, M. J. Stampfer, G. A. Colditz, and J. E. Manson Adiposity as Compared with Physical Activity in Predicting Mortality among Women N. Engl. J. Med., December 23, 2004; 351(26): 2694 - 2703. [Abstract] [Full Text] [PDF]
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D. R. Jacobs Jr. and M. A. Pereira Physical Activity, Relative Body Weight, and Risk of Death among Women N. Engl. J. Med., December 23, 2004; 351(26): 2753 - 2755. [Full Text] [PDF]
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S. T. St. Jeor, L. L. Hayman, S. R. Daniels, M. W. Gillman, G. Howard, C. M. Law, C. E. Lewis, and E. Poehlman Prevention Conference VII: Obesity, a Worldwide Epidemic Related to Heart Disease and Stroke: Group II: Age-Dependent Risk Factors for Obesity and Comorbidities Circulation, November 2, 2004; 110(18): e471 - e475. [Full Text] [PDF]
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S. Klein, L. E. Burke, G. A. Bray, S. Blair, D. B. Allison, X. Pi-Sunyer, Y. Hong, and R. H. Eckel Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation Circulation, November 2, 2004; 110(18): 2952 - 2967. [Abstract] [Full Text] [PDF]
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 A. Steadham Obesity Is NOT a Disease DOC News, October 1, 2004; 1(2): 10 - 10. [Full Text]
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S. N. Blair and T. S. Church The Fitness, Obesity, and Health Equation: Is Physical Activity the Common Denominator? JAMA, September 8, 2004; 292(10): 1232 - 1234. [Full Text] [PDF]
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 J. A. Laukkanen, S. Kurl, R. Salonen, R. Rauramaa, and J. T. Salonen The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study Eur. Heart J., August 2, 2004; 25(16): 1428 - 1437. [Abstract] [Full Text] [PDF]
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S. L. Norris, X. Zhang, A. Avenell, E. Gregg, C. H. Schmid, C. Kim, and J. Lau Efficacy of Pharmacotherapy for Weight Loss in Adults With Type 2 Diabetes Mellitus: A Meta-analysis Arch Intern Med, July 12, 2004; 164(13): 1395 - 1404. [Abstract] [Full Text] [PDF]
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S. Maru, Y. T van Der Schouw, C. H. Gimbrere, D. E Grobbee, and P. H. Peeters Body mass index and short-term weight change in relation to mortality in Dutch women after age 50 y Am. J. Clinical Nutrition, July 1, 2004; 80(1): 231 - 236. [Abstract] [Full Text] [PDF]
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 R. Rauramaa, P. Halonen, S. B. Vaisanen, T. A. Lakka, A. Schmidt-Trucksass, A. Berg, I. M. Penttila, T. Rankinen, and C. Bouchard Effects of Aerobic Physical Exercise on Inflammation and Atherosclerosis in Men: The DNASCO Study: A Six-Year Randomized, Controlled Trial Ann Intern Med, June 15, 2004; 140(12): 1007 - 1014. [Abstract] [Full Text] [PDF]
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P. W. Franks, U. Ekelund, S. Brage, M.-Y. Wong, and N. J. Wareham Does the Association of Habitual Physical Activity With the Metabolic Syndrome Differ by Level of Cardiorespiratory Fitness? Diabetes Care, May 1, 2004; 27(5): 1187 - 1193. [Abstract] [Full Text] [PDF]
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 D. Ashton Food advertising and childhood obesity J R Soc Med, February 1, 2004; 97(2): 51 - 52. [Full Text] [PDF]
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 P. M. Krueger, R. G. Rogers, R. A. Hummer, and J. D. Boardman Body Mass, Smoking, and Overall and Cause-Specific Mortality Among Older U.S. Adults Research on Aging, January 1, 2004; 26(1): 82 - 107. [Abstract] [PDF]
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T. S. Church, Y. J. Cheng, C. P. Earnest, C. E. Barlow, L. W. Gibbons, E. L. Priest, and S. N. Blair Exercise Capacity and Body Composition as Predictors of Mortality Among Men With Diabetes Diabetes Care, January 1, 2004; 27(1): 83 - 88. [Abstract] [Full Text] [PDF]
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E. I. M. Fransson, L. S. Alfredsson, U. H. de Faire, A. Knutsson, and P. J. M. Westerholm Leisure time, occupational and household physical activity, and risk factors for cardiovascular disease in working men and women: the WOLF study Scand J Public Health, October 1, 2003; 31(5): 324 - 333. [Abstract] [PDF]
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J. M. Jakicic, B. H. Marcus, K. I. Gallagher, M. Napolitano, and W. Lang Effect of Exercise Duration and Intensity on Weight Loss in Overweight, Sedentary Women: A Randomized Trial JAMA, September 10, 2003; 290(10): 1323 - 1330. [Abstract] [Full Text] [PDF]
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J. E. Gerich Clinical Significance, Pathogenesis, and Management of Postprandial Hyperglycemia Arch Intern Med, June 9, 2003; 163(11): 1306 - 1316. [Abstract] [Full Text] [PDF]
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J. E. Donnelly, J. O. Hill, D. J. Jacobsen, J. Potteiger, D. K. Sullivan, S. L. Johnson, K. Heelan, M. Hise, P. V. Fennessey, B. Sonko, et al. Effects of a 16-Month Randomized Controlled Exercise Trial on Body Weight and Composition in Young, Overweight Men and Women: The Midwest Exercise Trial Arch Intern Med, June 9, 2003; 163(11): 1343 - 1350. [Abstract] [Full Text] [PDF]
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V. Press, I. Freestone, and C.F. George Physical activity: the evidence of benefit in the prevention of coronary heart disease QJM, April 1, 2003; 96(4): 245 - 251. [Full Text] [PDF]
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 M Labib The investigation and management of obesity J. Clin. Pathol., January 1, 2003; 56(1): 17 - 25. [Abstract] [Full Text] [PDF]
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 M J Franz, H Warshaw, A E Daly, J Green-Pastors, M S Arnold, and J Bantle Evolution of diabetes medical nutrition therapy Postgrad. Med. J., January 1, 2003; 79(927): 30 - 35. [Abstract] [Full Text] [PDF]
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 R. M. Friedenberg Obesity Radiology, December 1, 2002; 225(3): 629 - 632. [Full Text] [PDF]
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J. Stevens, J. Cai, K. R. Evenson, and R. Thomas Fitness and Fatness as Predictors of Mortality from All Causes and from Cardiovascular Disease in Men and Women in the Lipid Research Clinics Study Am. J. Epidemiol., November 1, 2002; 156(9): 832 - 841. [Abstract] [Full Text] [PDF]
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T.S. Church, C.E. Barlow, C.P. Earnest, J.B. Kampert, E.L. Priest, and S.N. Blair Associations Between Cardiorespiratory Fitness and C-Reactive Protein in Men Arterioscler Thromb Vasc Biol, November 1, 2002; 22(11): 1869 - 1876. [Abstract] [Full Text] [PDF]
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 M. J. Franz 2002 Diabetes Nutrition Recommendations: Grading the Evidence The Diabetes Educator, September 1, 2002; 28(5): 756 - 766. [PDF]
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S. N. Blair and M. Z. Nichaman The Public Health Problem of Increasing Prevalence Rates of Obesity and What Should Be Done About It Mayo Clin. Proc., February 1, 2002; 77(2): 109 - 113. [PDF]
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M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]
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J. M. Hootman, C. A. Macera, B. E. Ainsworth, M. Martin, C. L. Addy, and S. N. Blair Association among Physical Activity Level, Cardiorespiratory Fitness, and Risk of Musculoskeletal Injury Am. J. Epidemiol., August 1, 2001; 154(3): 251 - 258. [Abstract] [Full Text] [PDF]
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 M. J. Franz The Answer to Weight Loss Is Easy--Doing It Is Hard! Clin. Diabetes, July 1, 2001; 19(3): 105 - 109. [Abstract] [Full Text] [PDF]
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F. B. Hu, M. F. Leitzmann, M. J. Stampfer, G. A. Colditz, W. C. Willett, and E. B. Rimm Physical Activity and Television Watching in Relation to Risk for Type 2 Diabetes Mellitus in Men Arch Intern Med, June 25, 2001; 161(12): 1542 - 1548. [Abstract] [Full Text] [PDF]
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J. F. Horowitz and S. Klein Oxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity J Appl Physiol, December 1, 2000; 89(6): 2276 - 2282. [Abstract] [Full Text] [PDF]
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R. Roubenoff and V. A. Hughes Sarcopenia: Current Concepts J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2000; 55(12): 716M - 724. [Abstract] [Full Text]
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National Task Force on the Prevention and Treatmen Overweight, Obesity, and Health Risk Arch Intern Med, April 10, 2000; 160(7): 898 - 904. [Abstract] [Full Text] [PDF]
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T. Rankinen, L. Perusse, J. Gagnon, Y. C. Chagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, and C. Bouchard Angiotensin-converting enzyme ID polymorphism and fitness phenotype in the HERITAGE Family Study J Appl Physiol, March 1, 2000; 88(3): 1029 - 1035. [Abstract] [Full Text] [PDF]
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F. W. Booth, S. E. Gordon, C. J. Carlson, and M. T. Hamilton Waging war on modern chronic diseases: primary prevention through exercise biology J Appl Physiol, February 1, 2000; 88(2): 774 - 787. [Abstract] [Full Text] [PDF]
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J. P. Koplan and W. H. Dietz Caloric Imbalance and Public Health Policy JAMA, October 27, 1999; 282(16): 1579 - 1581. [Full Text] [PDF]
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, fit; 
, unfit. Fit, lean men comprised the reference category, represented by the heavy line at 1.0. Unfit men were the least-fit 20% of each age group, and fit refers to all other men (
